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The Language of Elution: Autoregressive Prediction of the Next Feature in Untargeted LC-HRMS Lipidomics
Announce Type: cross Abstract: Untargeted liquid chromatography-high-resolution mass spectrometry (LC-HRMS) detects thousands of molecular features per sample, yet only 2-20% receive confident structural annotations. A root cause of this "dark metabolome" is that tandem MS/MS acquisition is reactive: instruments select precursors only after ions appear, blind to what elutes next. We reframe chromatographic elution as an autoregressive sequence prediction task.
LC-ERD: Mining Latent Logic for Self-Evolving Reasoning via Consistency-Regulated Reward Decomposition
arXiv:2605.24005v2 Announce Type: replace Abstract: The evolution of Large Language Model (LLM) reasoning is bottlenecked by the scarcity of high-quality process data. While self-alignment via endogenous rewards offers a solution, mining valid supervision faces three challenges: (1) Label Noise via Mimetic Bias, where rewards prioritize statistical likelihood over logical truth, creating a "correctness illusion" that masks compounding errors; (2) Coarse-Grained Supervision, where sparse...
LC-MS Metabolomics Reveals No Significant Impact of Microbial Inoculation with Bacillus velezensis and Lachnum sp. on Cranberry Metabolome
Sustainable agriculture has driven increased exploration of microbial inoculants as a promising strategy to boost plant growth for higher yield and enhance secondary metabolism to increase crop nutritional value. However, their influence on fruit-specific metabolites under field conditions remains understudied. This study investigated the impact of inoculating cranberry (Vaccinium macrocarpon) plants with Bacillus velezensis EB37 and Lachnum sp. EC5, applied individually and in combination,...
LC-SAC: Lyapunov-Constrained Soft Actor-Critic via Koopman Operator Theory for Trajectory Tracking and Stabilization
arXiv:2602.04132v4 Announce Type: replace Abstract: Reinforcement Learning (RL) has achieved remarkable success in solving complex sequential decision-making problems. However, its application to safety-critical physical systems remains constrained by the lack of stability guarantees. Standard RL algorithms prioritize reward maximization, often yielding policies that may induce oscillations or unbounded state divergence.
Locus coeruleus activation transforms cortical taste representations
Norepinephrine neurons in the locus coeruleus (LC) shape sensory responses across the brain, yet how LC activity reorganizes population representations of behaviorally relevant sensory attributes remains unclear. We addressed this question in the primary gustatory cortex (GC), a system largely unexplored in neuromodulation research and well-suited for linking sensory coding to affective value. Using miniscope calcium imaging in awake mice combined with optogenetic LC activation, we tested...
Blue Origin says New Glenn rocket will launch again 'before the end of the year' after explosion
Blue Origin says New Glenn rocket will launch again 'before the end of the year' after explosion And there's only about half of the year left… After its rocket explosion, Blue Origin wants to complete repairs and put another New Glenn on the launchpad before the end of 2026, according to CEO Dave Limp. That's very ambitious. The company's New Glenn rocket stood at Launch Complex-36 (LC-36) at Cape Canaveral Space Force Station last Thursday (May 28) for a static hot fire test ahead of the...
Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticty
arXiv:2511.04726v2 Announce Type: replace Abstract: To investigate the mechanical correlations between intraocular pressure (IOP) variations and glaucoma, this study presents a linear transversely isotropic poroelastic model of the lamina cribrosa (LC) based on Reissner-Mindlin plate theory. A key feature of the proposed framework is its analytical tractability, which allows the governing poroelastic equations to be solved in closed form under appropriate mechanical and hydraulic boundary...
RISOP, a Reference-Assisted Approach for Enhanced Identification of Oxidized Phospholipids
Oxidized phospholipids (OxPLs) play critical roles in inflammation, ferroptosis, and other oxidative stress-associated processes, yet their systematic characterization in biological systems remains a major analytical challenge owing to their low abundance and vast structural diversity. Here we report RISOP (Reference-Assisted Identification of Sample-specific Oxidized Phospholipids), an untargeted LC-MS/MS workflow that leverages chemically enriched OxPL reference pools to substantially...
Discovery of BilV reveals a multienzymatic basis for bilirubin reduction across vertebrate gut microbiomes
Gut bacteria reduce bilirubin to urobilinogen, allowing it to be excreted through feces and urine, but studies have long noted a heterogeneous mixture of partially reduced bilirubin-derived intermediates, suggesting that multiple enzymes are involved. Here we identify bilirubin vinyl reductase (BilV), a novel Old Yellow Enzyme family reductase encoded in the genomic neighborhood of the known bilirubin reductase (bilR). Using heterologous expression and LC-MS/MS, we show that BilR acts on the...
Blue Origin has set a very aggressive return-to-flight timeline
The chief executive of Blue Origin, whose large New Glenn rocket exploded spectacularly less than a week ago at the company's launch site in Florida, vowed Monday night that the company would launch again before the end of 2026. Writing on the social media site X, Blue Origin's Dave Limp said the company had been able to complete a preliminary survey of the LC-36A launch site. "Now that we’ve had access to the pad and integration facility, we can share a bit of good news," Limp said.