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Decentralized Stochastic Nonconvex Optimization under the $(L_0,L_1)$-Smoothness

arXiv:2509.08726v3 Announce Type: replace-cross Abstract: This paper focuses on the decentralized stochastic optimization problem $f(\mathbf{x})=\frac{1}{m}\sum_{i=1}^m f_i(\mathbf{x})$ over a connected network of $n$ agents, where each local function has the form of $f_i(\mathbf{x}) = {\mathbb E}\left[F(\mathbf{x};{\boldsymbol \xi}_i)\right]$ which satisfies the $(L_0,L_1)$-smooth condition but possibly nonconvex and each random variable ${\boldsymbol \xi}_i$ follows distribution ${\mathcal...

arXiv CS 7d ago

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.

Nature 17h ago

Infinite sequences with optimal diaphony, periodic $L_2$-discrepancy, and beyond

arXiv:2606.05482v1 Announce Type: new Abstract: We investigate the periodic $L_2$-discrepancy of infinite sequences $\S_d$ in $[0,1)^d$ and its analytic counterpart, the diaphony. We prove that infinite order-2 digital sequences over $\mathbb{F}_2$ attain the optimal order $L_{2,N}^{{\rm per}}(\S_d) \le C_d (\log N)^{d/2}/N$ for all $N \in \mathbb{N}\setminus \{1\}$, matching known lower bounds for infinitely many $N \in \mathbb{N}$.

arXiv CS 5d ago

Predicting every game of the entire World Cup: All...

Everyone is using artificial intelligence to do, well, everything. With the World Cup starting on June 11, you can't scroll for more than a couple of minutes without hitting another post or video or reel of someone telling you how they used AI to predict the World Cup. So, I decided to use my own supercomputer to predict every game of the 2026 World Cup -- the supercomputer is called "my brain."

ESPN 5d ago

Ultrafast machine learning on FPGAs via Kolmogorov-Arnold Networks

Ultrafast machine learning on FPGAs via Kolmogorov-Arnold Networks This post is a high-level explainer for my Master’s thesis, which involves designing hardware architectures for ultrafast inference and online learning using the Kolmogorov-Arnold Network (KAN) architecture. I’ll assume familiarity with standard machine learning concepts, as well as some understanding of hardware and digital circuits; read my previous post here for the latter. Please read the two papers below for more...

Hacker News 21h ago

FIFA World Cup 2026: Full schedule, fixtures, groups, India timings, venues, knockout dates

The FIFA World Cup 2026 is set to usher in a new era for international football, with the tournament expanding to 48 teams for the first time in its history. Co-hosted by the United States, Canada and Mexico, the month-long spectacle will run from June 11 to July 19, 2026 (June 12 to July 20 in India), bringing together 48 nations, 1,248 players and a record 104 matches across 16 host cities. The expanded format means more teams, more matches, more knockout football and a longer route to the...

Times of India 1d ago

Test-case reducers are underappreciated debugging tools

Test-case reducers are less well known than they should be, and those who are aware of them don’t always realise the variety of ways we can use – perhaps even abuse! – them. In this post, I’m going to explore some of the things I’ve learnt while using these wonderful tools. I’ll start at the basics, because the idea is so simple that it can be hard to believe it works.

Hacker News 1d ago

Amplified Arctic iceberg traffic reshapes benthic biodiversity

Abstract The Arctic is undergoing rapid warming, resulting in retreating sea ice and glaciers1, yet how cryospheric changes propagate into the deep ocean remains poorly understood2. Here we identify a climate-driven mechanism linking accelerating glacier disintegration to an increase in deep-sea hard-bottom habitats far beyond calving fronts. Seafloor observations in Fram Strait show a localized increase in the density and patchiness of dropstones delivered by debris-laden icebergs.

Nature 17h ago

Gene ancestries reveal diverse microbial associations during eukaryogenesis

Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.

Nature 17h ago

A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone

Abstract Whale falls are biodiversity oases at seabeds1,2,3,4,5,6, yet their record from the oceans has remained sparse and fragmentary6,7. Here we report the discovery of a vast whale necropolis in the Diamantina Zone (4,616- to 7,001-m depth), extending about 1,200 km along the sea floor of the southeastern Indian Ocean. This area has a deep and extensive accumulation comprising five modern natural whale-fall communities and 476 fossil cetaceans recorded.

Nature 17h ago