Lachnospiraceae
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Fusion of a non-specific DNA-binding domain enhances Cas12a trans-cleavage for robust nucleic-acid diagnostics
CRISPR-Cas12a underlies powerful genome-editing and nucleic-acid detection technologies, yet its performance is limited by inefficient target engagement and low catalytic turnover, particularly at low target abundance and elevated temperatures. Here, we report a modular protein-engineering strategy to enhance Cas12a trans-activity by fusing the hyperthermophilic DNA-binding protein Sso7d to the N terminus of Lachnospiraceae bacterium ND2006 Cas12a (LbaCas12a). The resulting fusion enzyme...
Microbial community profiles of the snake cloaca in the presence and absence of Chlamydiota
Chlamydiota are obligate intracellular bacteria detected in snake cloacal microbiota, yet their biological significance remains poorly understood. Members range from recognised pathogens, such as Chlamydia serpentis, to potential environmental symbionts, raising questions about whether they represent transient contaminants, persistent colonisers, or subclinical infectious agents. Despite the cloaca serving as a primary site of chlamydial shedding in snakes, its interaction with the broader...