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Retatrutide: Triple acting jab for type 2 diabetes lowers blood sugar and boosts weight loss, trial reports
Retatrutide, a triple action treatment for type 2 diabetes, could significantly reduce blood glucose concentrations and body weight in patients with the condition, a phase 3 trial has reported. The results, published in the Lancet,1 show that patients who received injections of retatrutide for 40 weeks lost more than four times as much weight as those in the placebo group. After 40 weeks the average reduction in HbA1c with the new treatment was more than twice that in the placebo group,...
'The Real Scoreline' reveals the nations facing climate penalties
'The Real Scoreline' reveals the nations facing climate penalties Stephanie Baum Scientific Editor Andrew Zinin Lead Editor As nations prepare to compete on the global stage this summer, researchers at the University of Reading have created a different kind of scoreboard that shows where each country really stands on climate change. The Real Scoreline compares countries using six climate indicators—including emissions, fossil fuel dependence, heat stress, projected warming and net-zero...
Wildfires reverse decade of ozone cleanup in the United States, study reveals
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A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Doctors thought this kidney drug helped some patients. It may help millions more.
Doctors thought this kidney drug helped some patients. It may help millions more. - Date: - June 8, 2026
This drug delayed rheumatoid arthritis for years after treatment ended
This drug delayed rheumatoid arthritis for years after treatment ended - Date: - June 1, 2026 - Source: - King's College London - Summary: - A promising new study suggests rheumatoid arthritis may not be as inevitable as once thought for people at high risk. Researchers found that just one year of treatment with the immune-targeting drug abatacept delayed the onset of rheumatoid arthritis by up to four years, with benefits lasting long after treatment ended. - Share: People at high risk of...
Show HN: Breathe CLI – Paced resonance breathing in the macOS terminal
I built a terminal app that paces slow breathing at 6 breaths per minute for vagal tone training. It's a single Python file, stdlib only, no dependencies — just run breathe and follow the bar. I'm a cardiology patient (HFrEF).