Leishmania mexicana
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Related Articles from SNS
Active transcriptome remodeling and epigenetic adaptations underlie persistence in Leishmania parasites
Persistence - characterized by the transient ability of subpopulations of drug-susceptible parasites to survive exposure to drug - is a major driver of treatment failure and clinical relapses in leishmaniasis. Persisters are characterized by non-dividing or slow-growing state and increased drug tolerance. However, the molecular mechanisms governing formation of persisters remain poorly understood in Leishmania parasites.