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A drone alert blasted on my phone – we had to take shelter. This is the new reality on Nato’s eastern flank | Linas Kojala
In Lithuania, and throughout the Baltic, we have lived for years with Russian hostility – but the tech now means that London, Berlin and Paris are just as vulnerableA couple of weeks ago, I was walking through the streets of Vilnius, on my way to give a talk on geopolitics to a group of visiting Austrian business and academic leaders. It was a pleasant spring day: people were out and about, cafe tables were set outside – all the familiar tranquillity of a European capital that has grown used...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Man sentenced to 10 years in jail for stabbing death of niece in Darwin
Andrew Mungatopi sentenced to 10 years in jail for stabbing death of Tiwi Islands sistergirl Thu 11 Jun 2026 at 5:03pm In short: Andrew Mungatopi has been sentenced to 10 years and two months in prison for the fatal stabbing of his niece in the backyard of a Malak home in October 2024. He was found not guilty of murder, but guilty of manslaughter, following a week-long trial in the Northern Territory Supreme Court in April.
Two years after Israel’s Nuseirat ‘rescue’ success, we are still bleeding
Two years after Israel’s Nuseirat ‘rescue’ success, we are still bleeding My family survived the massacre that freed four captives and killed hundreds of innocents. Its wounds and nightmares have not left us. In May 2024, after seven months of displacement and moving between tents and other people’s houses, we returned to Nuseirat refugee camp in central Gaza.