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Related Articles from SNS
Locus coeruleus activation transforms cortical taste representations
Norepinephrine neurons in the locus coeruleus (LC) shape sensory responses across the brain, yet how LC activity reorganizes population representations of behaviorally relevant sensory attributes remains unclear. We addressed this question in the primary gustatory cortex (GC), a system largely unexplored in neuromodulation research and well-suited for linking sensory coding to affective value. Using miniscope calcium imaging in awake mice combined with optogenetic LC activation, we tested...
The Exponential of Skew-Symmetric Matrices: A Nearby Inverse and Efficient Computation of Derivatives
arXiv:2506.18302v2 Announce Type: replace-cross Abstract: The matrix exponential restricted to skew-symmetric matrices has numerous applications, notably in view of its interpretation as the Lie group exponential and Riemannian exponential for the special orthogonal group. We characterize the invertibility of the derivative of the skew-restricted exponential, thereby providing a simple expression of the tangent conjugate locus of the orthogonal group. In view of the skew restriction, this...
Refining Word-Based Grammatical Error Annotation for L2 Korean
Announce Type: new Abstract: Korean grammatical error correction (K-GEC) presents a structural mismatch between word-based evaluation and the morpheme-level locus of many learner errors. Postpositions and verbal endings are bound to lexical hosts, but they encode grammatical relations that must be represented in correction and evaluation. This paper refines word-based grammatical error annotation for L2 Korean by addressing three connected problems in existing resources: surface target...
Two melanic pigment patterns are associated with a sex chromosome-linked oncogene in the mountain swordtail Xiphophorus nezahualcoyotl
Sex-linked traits are widespread, but their genetic architecture has been challenging to characterize, due in part to the repetitive and structurally complex nature of sex chromosomes. In swordtails and platyfish of the genus Xiphophorus, diverse melanic pigmentation patterns are thought to be controlled by a region on the sex chromosomes classically referred to as the "macromelanophore determining locus". Despite nearly a century of study, the identity of the causal gene remains...
Genome editing of key domestication genes overcomes self-incompatibility and bitter taste in cultivated buckwheat
Buckwheat (Fagopyrum spp.) is a climate-resilient pseudocereal, yet its global adoption is constrained by the distylous self-incompatibility of common buckwheat (F. esculentum) and grain bitterness of Tartary buckwheat (F. tataricum). While the S-locus early flowering 3 (FeS-ELF3) gene has been identified as a key regulator of self-compatibility, a stable genetic transformation of F. esculentum has not yet been developed. In this study, we developed an Agrobacterium-mediated transformation...
Imputed graph-genotyped structural variants identify regulatory haplotypes associated with gene expression in Atlantic salmon
Structural variants (SVs) can affect gene regulation, but they are difficult to include in expression genetic studies when large RNA-seq cohorts lack whole-genome sequencing. This is common in non-human and non-model systems, where whole-genome sequencing at population scale remains costly. As a result, expression quantitative trait locus (eQTL) studies often rely on single nucleotide polymorphism (SNP) markers.
The ASD Risk Gene D5Ertd579e Regulates Synaptic Plasticity and Selective Autism-Related Behaviors
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition shaped by contributions from hundreds of genes, many of which remain poorly characterized. This largely uncharacterized genomic landscape may therefore hold critical insight into how diverse molecular disruptions converge on shared social phenotypes. Here, we investigated KIAA0232 (mouse orthologue D5Ertd579e), an uncharacterized locus lacking known functional domains, using a global null knockout mouse model.
Satellite DNA Editing Enables Meiosis-Independent Chromosome Engineering
Chromosome-scale genome engineering in plants typically relies on locus-specific recombination during meiosis to select desirable outcomes, limiting its application in species with long generation times. Here, we show that CRISPR targeting of abundant satellite DNA enables multiplexed chromosome restructuring in aspen, generating diverse large-scale structural variants in the first generation. These megabase rearrangements remain mitotically stable through clonal propagation and regeneration...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.