Lox
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Related Articles from SNS
Hypertension-mediated cardiac fibrosis is a mechanical process initiated by smooth muscle cells
Hypertension represents the most prevalent chronic cardiovascular condition, typically culminating in pathological cardiac remodeling characterized by hypertrophy and extensive fibrosis. Although the cellular phenotypes associated with these changes are well-documented, the precise mechanisms by which hypertensive stress is sensed and transduced into a fibrotic program remain poorly defined. To elucidate these mechanisms, we investigated the role of Lysyl oxidase (LOX), an extracellular...
Should your dog have its own bedroom? Does your cat need a bathroom? The rise and rise of the pet nook
More and more of our furry friends are getting their own living spaces, complete with soft furnishings and decorations. We asked some of the owners whyLox is sprawled out on a green sofa, bathed in warm light from a standing lamp, framed art on the wall behind him. This may sound like a relatively ordinary description of someone in their living room – except that Lox is a cat, not a human, and the “living room” he shares with another cat, Lottie, is a converted cupboard in a New York apartment.
The American Missile Crisis
Recent global conflicts, from Russia and Ukraine to Iran and Israel, have seen a resurgent awareness of the frailty of US munitions stock, which has been drawn down by both direct and indirect involvement in these events. While exact stockpile volumes are not disclosed, it is estimated that supplies of US warheads and the missiles that carry them have declined by nearly an order of magnitude since their peak during the Cuban Missile Crisis. Analysts have estimated that in the event of a...
Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma
Loss of the Y chromosome (LOY) is associated with poor survival across multiple solid tumors, yet the underlying molecular mechanisms remain poorly understood. Here, we identify LOY as a central driver of lineage plasticity and epigenetic heterogeneity in lung adenocarcinoma. Integrating multi-omic profiling of primary samples with isogenic cellular models, we show that LOY triggers epithelial-to-mesenchymal transition (EMT).