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Impairment of bacteriophage activity in blood: a case study revealing constraints in phage isolation and translation

Background Phage therapy is increasingly considered a promising alternative for treating multidrug-resistant (MDR) infections. However, its clinical application remains limited by challenges in isolating effective phages against resistant clinical strains and by the limited ability of in vitro assays to predict performance in real biological environments. While biological matrices are known to influence phage activity, these effects are not well characterised.

bioRxiv 9d ago

PFT: Phonon Fine-tuning for Machine Learned Interatomic Potentials

Announce Type: replace-cross Abstract: Many materials properties depend on higher-order derivatives of the potential energy surface, yet machine learned interatomic potentials (MLIPs) trained with a standard loss on energy, force, and stress errors can exhibit error in curvature, degrading the prediction of vibrational properties. We introduce phonon fine-tuning (PFT), which directly supervises second-order force constants of materials by matching MLIP energy Hessians to DFT-computed force...

arXiv CS 8d ago

Sky spectacle: where to see the northern lights in Germany this weekend

According to the US weather agency NOAA, solar storms are forecast for the weekend that could produce vivid auroras, or northern lights, across North America and Canada. In the United States, the weather monitoring agency has announced that the northern lights could be visible in the northern United States and Canada, as strong geomagnetic storms are expected. These could also light up the skies over Germany, especially in the north and along the coasts, during the night of 5 to 6 June.

Euronews 5d ago