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Redundant γc cytokines license IL-1-driven neutrophil inflammation through MEK/ERK convergence

Interleukin 1 (IL1) is a central driver of autoinflammatory disease, yet IL1 blockade often provides incomplete benefit in complex, neutrophil-driven conditions. Here we identify a licensing circuit in which common gamma chain cytokines provide a redundant signal required for maximal IL1 driven neutrophil inflammation. IL1 and gamma chain cytokines synergize to drive inflammatory cytokine production exceeding either stimulus alone, and these signals engage the MEK/ERK pathway, an effect...

bioRxiv 9d ago

Iran allegedly used soccer clubs to spy on citizens, opposition group urges FIFA to ban team before World Cup

Iran's Islamic Revolutionary Guard Corps (IRGC) has allegedly used the country's soccer system to spy on citizens, potentially violating FIFA bylaws, according to a new report from a major opposition party. The National Council of Resistance of Iran (NCRI)'s U.S. office provided the report to Fox News Digital. It outlines an alleged plot for Iran’s soccer federation and top clubs to be drawn into a broader state security apparatus, and that at least 15 IRGC commanders have been formally...

Fox News 5h ago