Macromolecules
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Related Articles from SNS
Cooperative Conformational Transitions in Macromolecules under Mechanical Stretching. An Exactly Solved Model for Single Molecule Experiments
arXiv:2605.31462v1 Announce Type: cross Abstract: The stretching behavior of linear macromolecules undergoing conformational transitions is investigated. An exact solution is provided for a two-state system within the elastic freely jointed chain model. This minimal framework contains the smallest set of parameters required to describe such transitions: two Kuhn lengths, two elastic force constants, a free energy difference between both states and a nearest-neighbor interaction energy...
A pectin and chitosan film to protect bioactive compounds in foods and therapies
A pectin and chitosan film to protect bioactive compounds in foods and therapies Lisa Lock Scientific Editor Andrew Zinin Lead Editor Researchers at IMDEA Materials Institute and the Institute of Polymer Science and Technology (ICTP-CSIC) have developed an innovative biodegradable multilayer film capable of protecting and controlling the release of anthocyanins inside the body. Published in the International Journal of Biological Macromolecules, this innovation opens the door to more...
Direct Detection and Atomic Modeling of Ligands in Cryo-EM Maps Using Deep Learning
Cryogenic electron microscopy (cryo-EM) has become an increasingly important for structure-based drug discovery by enabling characterization of interactions between macromolecules and small-molecule ligands. However, computational interpretation of ligand density remains challenging, particularly when ligand locations are unknown or local map resolution is limited. Existing methods generally require well-resolved macromolecular structures and predefined binding sites, limiting their...
Geometric shape matching for recovering protein conformations from single-particle Cryo-EM data
Announce Type: replace-cross Abstract: We address recovery of the three-dimensional backbone structure of single polypeptide proteins from single-particle cryo-electron microscopy (Cryo-SPA) data. Cryo-SPA produces noisy tomographic projections of electrostatic potentials of macromolecules. From these projections, we use methods from shape analysis to recover the three-dimensional backbone structure.
Thousandfold Expansion Microscopy
Biological macromolecules, such as proteins, are made of concatenated building blocks. We hypothesized that individual protein residues could be imaged by anchoring their side chains to a swellable polymer, cleaving backbone amide bonds, and expanding residues away from each other to a degree that enables them to be visualized separately. We introduce thousandfold expansion microscopy (1000ExM), a four-network interpenetrating hydrogel architecture that enables successive expansion from...
Nucleic acid 3D structure search and alignment with GTalign
Structural comparison of nucleic acids, particularly RNA, is critical for understanding evolutionary and functional relationships beyond sequence similarity, yet efficient tools for large-scale 3D structure search and alignment remain scarce. We extend GTalign to support nucleic acid structures, enabling unified, high-performance alignment across macromolecules. Benchmarking on a diverse RNA dataset demonstrates improved alignment accuracy and substantially lower runtimes compared to...
A Conformation-Centric Generative Foundation Model for Linear Polymer Modeling and Design
arXiv:2510.16023v2 Announce Type: replace Abstract: Linear polymers, macromolecules formed from monomers covalently bonded into continuous chains, underpin countless technologies and are indispensable to modern life. While deep learning is advancing polymer science, existing methods typically represent the whole linear polymer solely through monomer-level descriptors, overlooking the global structural information inherent in polymer conformations, which ultimately limits their practical...
Microfluidic Oscillatory Rheology of Transported Soft Particles
arXiv:2605.29842v2 Announce Type: replace-cross Abstract: Microfluidic channels have emerged as useful tools to control dynamic forcing on transported microscale objects, as encountered in emulsions, biological flows, and other soft matter systems. Tailored channel designs enable precise interfacial and bulk rheological measurements of complex materials over a wide range of forcing timescales. After a brief overview of recent experiments illustrating these techniques, we discuss perspectives...