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Antibody maturation increases rigidity in protein-contacting regions and flexibility at glycan interfaces
Antibody design is a challenging task that could be improved by understanding the conformational changes accompanying affinity maturation. Antibody maturation is a critical immune system process by which antibodies gain mutations that improve affinity and specificity for antigen targets. However, how these mutations change antibody dynamics, specifically whether antibodies become more rigid as they mature, remains a contested topic.
Advancing Digital Government: Integrating Open Source Software Enablement Indicators in Maturity Indexes
arXiv:2510.04603v2 Announce Type: replace Abstract: Context: Open Source Software (OSS) is a vital public good, included across most of modern software stacks, significantly impacting GDP and national tech growth, while supporting interoperability, sovereignty, and transparency. However, systematic measurement of governmental OSS adoption remain limited. Research Aim: This study contributes to digital government maturity indexes by analyzing policies and support actions leveraging OSS for...
Architecting Strategic Influence: Operationalising the UXR Point of View Framework for Research Function Maturity
arXiv:2606.05826v1 Announce Type: new Abstract: This case study illustrates that the systematic application of the User Experience Research (UXR) Point of View (POV) framework serves as an effective operational scaffolding for a UXR function undergoing the critical transition from incubation to maturity. By assimilating structured 'Offensive' and 'Defensive' strategies, the presented Playbook equips UXR leaders with an adaptable toolkit to systematically navigate common institutional...
Look for these ingredients in a moisturizer for mature skin
Skin becomes drier as we age; that’s why adding moisture to the skin is key for those with mature skin.
Mature Marcus Smith inspires Harlequins comeback to dent Exeter’s play-off hopes
Mature Marcus Smith inspires Harlequins comeback to dent Exeter’s play-off hopes
Maturation of Gait: Identification of Locomotor Profiles from Early Childhood to Adulthood
Background: Human gait is a key marker of motor development. While walking on even surface is well-documented, responses to irregular surfaces, closer to real-world environments, remain understudied. This limitation is reinforced by the frequent use of univariate analyses, though locomotor control emerges from interactions of multiple features.
Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation
Insulinomas are rare and benign human pancreatic adenomas that overproduce insulin and display increased beta cell mass. We and others have shown that transcriptomic and genomic profiling on insulinomas provides a data mine for identifying targets that can be manipulated to induce human beta cell regeneration. Majority of causative genetic variants in insulinomas involve epigenetic regulatory genes.
AI will help young workers 'mature' faster by automating grunt work, Thoma Bravo says, amid youth job crisis
Thoma Bravo's billionaire founder says AI will transform junior workers' roles by eliminating grunt work, despite growing concerns about the technology's impact on entry-level roles. Orlando Bravo, the founder of software-focused private equity firm Thoma Bravo, discussed how the role of junior associates is changing as the company increasingly utilizes AI, in a conversation with CNBC's Annette Weisbach at the SuperReturn conference in Berlin on Tuesday. The jobs of junior associates will...
Closing the Alignment-Maturity Gap in Federated Prototype Learning
Announce Type: new Abstract: Learning discriminative visual representations from distributed, heterogeneous data is a fundamental challenge in Federated Learning (FL). Prototype-based methods address statistical heterogeneity by sharing class-level representations across clients but create a distance-dependent gradient pressure that is particularly severe during early training rounds: alignment pressure applied to immature global prototypes, aggregated from noisy local representations,...
Landmark finding that showed brains of kids with ADHD mature later was actually a mirage in the data, new research finds
A new study reveals more insights into how ADHD affects young brains.