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China’s SAIC to Make MG Cars at First European Factory in Spain
Members of the media look at the MG Hector sports utility vehicle (SUV) on display during the vehicle's launch at the Morris Garages flagship showroom in Gurugram, Haryana, India, on Thursday, June 27, 2019. The launch of the Hector from the iconic brand MG, now owned by Chinese giant SAIC Motor Corp., marks the first Chinese entrant in a notoriously difficult market where the likes of General Motors Co. and Ford Motor Co. have struggled.
Certain people taking ramipril for blood pressure told 'check for symptoms' after error
Certain people taking ramipril for blood pressure told 'check for symptoms' after error The MHRA has set out the symptoms which mean some people need to get medical help as it might be 'more serious' for group of patients People taking a common blood pressure medication have been urged to carry out an important check after a mistake was made putting some people at risk. A ramipril packaging error means some people may have been given 10mg capsules in a box labelled 2.5mg.
Geodesic Semantic Search: Cartographic Navigation of Citation Graphs with Learned Local Riemannian Maps
arXiv:2602.23665v5 Announce Type: replace Abstract: We present Geodesic Semantic Search (GSS), a retrieval system that learns node-specific Riemannian metrics on citation graphs to enable geometry-aware semantic search. Unlike standard embedding-based retrieval that relies on fixed Euclidean distances, \gss{} learns a low-rank metric tensor $\mL_i \in \R^{d \times r}$ at each node, inducing a local positive semi-definite metric $\mG_i = \mL_i \mL_i^\top + \eps \mI$.
BOKBO (Best of K Bad Options): Calibrated Abstention for VLA Policies
arXiv:2605.30660v1 Announce Type: new Abstract: Test-time scaling for vision-language-action (VLA) policies, methods such as RoboMonkey, SEAL, MG-Select, and V-GPS, samples K candidate action chunks at inference and executes the verifier-best. When all K candidates are unsafe, the system executes a violating action with no warning. We propose BOKBO, the first conformal abstention layer for K-sample VLA inference, providing finite-sample distribution-free guarantees on executed-violation rate.
Pharmacist warns of shortage of 188 common NHS drugs - full list
Pharmacist warns of shortage of 188 common NHS drugs - full list Pharmacist says NHS drugs shortage is the 'worst' he's known as supply issues hit dozens of common medications A pharmacist has warned that the current drugs shortage is the 'worst I've ever known' as supply problems affect dozens of everyday medicines. Some drugs used to treat conditions ranging from high blood pressure to diabetes are running low, with certain patients reportedly struggling to obtain their regular...
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Life-saving breast cancer and endometriosis drug to be discontinued
AstraZeneca pulls critical breast cancer and endometriosis drug Zoladex from shelves Thu 4 Jun 2026 at 4:49am In short: AstraZeneca has announced it will pull a critical breast cancer and endometriosis drug from Australian shelves from November. Patients have labelled the decision "cruel" and say they have been blindsided. AstraZeneca says it will provide free access to the drug for six months for those without alternative treatment pathways.
Lignin to adipic acid in a high-yield chemical and biological redox process
Abstract Viable manufacturing pathways to produce bio-based chemicals from renewable feedstocks, such as lignin derived from plant biomass, are needed to decarbonize the chemicals manufacturing sector. Converting the recalcitrant lignin polymer to valuable bioproducts remains a longstanding challenge in biorefining, with the highest reported single-product yield from lignin currently around 20 wt% (refs. Most existing lignin depolymerization strategies target aryl–ether bond cleavage, which...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
'Invisible' nicotine grips young people and raises alarm among public health experts
After the WHO warned that nicotine pouches may be addictive and harm brain development, their use is rising in Portugal amid legal limbo, while officials and experts debate regulation of a booming market. Small, discreet and smokeless. Nicotine pouches are gaining ground in Portugal, even before a full legal framework exists for their sale and advertising.