Molecular Cell
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Related Articles from SNS
Physicists discover attractive forces between molecular condensates may cause running off
Inside cells, certain functions are carried out by locally adjusting molecular composition. This condensation of material results in the formation of dense droplets that can dynamically rearrange. Because of this, interactions between such dense regions determine the shaping of condensates.
Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer's disease mouse model
Selective neuronal vulnerability is a defining feature of Alzheimer's disease, yet how neurodegeneration unfolds across defined hippocampal CA1 pyramidal neuron populations remains unresolved. Previously, we showed that CA1 pyramidal neurons are organized into molecularly defined laminar cell types that form stable spatial signatures along the longitudinal axis (Pachicano et al., 2025). Here, we investigated how vulnerability manifests across CA1 pyramidal cell types in the 5xFAD mouse model...
Single-cell gene regulatory network reconstruction and key regulator identification using a dual-channel fusion graph convolutional network
Background and objective: Gene regulatory networks are formed by complex regulatory relationships between transcription factors and their target genes. A systematic understanding of these regulatory relationships is crucial for deciphering the molecular mechanisms that underlie cell state transitions under physiological and pathological conditions. Single-cell expression data can reveal cell-type-specific transcriptional regulation, and computational methods have recently been developed to...
A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology.
Because cells are complex dynamical systems, modeling cellular behaviors requires methods that capture how cells evolve across time, environments, and interventions. Microscopy is uniquely suited to this goal in that it can be applied to living cells in their native context. However, the phenotypic resolving power of live-cell microscopy remains incompletely characterized, particularly relative to molecular assays.
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA
Enteroendocrine cells (EECs) are specialized sensors of the gastrointestinal (GI) epithelium that regulate gut function and systemic metabolism through hormone secretion. The molecular pathways directing intestinal stem cell (ISC) differentiation into EECs are incompletely understood due, in part, to their rarity. We sought to identify novel regulators of human EEC differentiation using a high-throughput screen of FDA-approved drugs and human duodenal organoids.
RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route
RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route Gaby Clark Scientific Editor Robert Egan Associate Editor IS110 transposons are a large, diverse family of bacterial insertion sequences (IS elements)—small, mobile DNA elements that can move from one genomic location to another. They have recently attracted broad interest due to the finding that some of these transposons use a bridge RNA (bRNA) to recognize both donor DNA and target DNA. Upon...
SOX9 regulates endothelial tip cell specification to promote cerebral and neuroretinal vascularization
Background: Tissue vascularization relies on the organotypic specification of endothelial tip cells to interpret local cues and guide angiogenic sprouts into specific tissue compartments. However, the molecular regulators controlling brain and retinal endothelial tip cell identity remain poorly understood. Methods: Endothelial-specific Sox9 loss-of-function mouse was combined with single-cell, spatial, and bulk RNA sequencing analyses of developing mouse brain and retinal vasculature, as...
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma
Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a tumor type with a high lethality due to late diagnosis and profound resistance to conventional chemotherapy. To date the molecular mechanisms underlying multidrug resistance remain poorly defined. Here, we integrate single-cell transcriptomics, clinicopathological analysis, and functional genomics to elucidate the molecular basis of cisplatin resistance in iCCA.
Sex and Alternative Splicing in Disease: a meta-analytic approach to identify interactions
How cell type, sex and disease interact and affect gene expression and splicing is an important, but complicated question. Visualizing and testing specific hypotheses around these complex interactions is an important first step to identifying molecular components underpinning complex disease. Using a meta-analytical framework, we develop an analytical path for identifying testable molecular hypotheses of complex interactions between splicing, sex, disease and cell type.
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...