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Melbourne aged care COVID outbreak back in spotlight
An inquest examining 50 deaths at a Melbourne aged care home has resumed after a years-long hiatus. St Basil's Home for the Aged managers Kon Kontis and Vicky Kos were the final two witnesses listed to give evidence at the inquest, which had previously heard about disastrous failures at the Fawkner centre. Coroner Liberty Sanger said the inquest would resume in the week of August 3, with Mr Kontis and Ms Kos to be questioned in the witness box.
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.