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Related Articles from SNS
Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence
Although spread of internalized Mtb from the initial infected alveolar macrophages (AMs) is a crucial determinant of infection outcomes, the role of cell death in facilitating this spread, and how it is regulated by Mtb remains poorly understood. Ferroptosis, a lipid peroxidation-mediated form of necrotic cell death, contributes to pathology during later stages of infection. However, the role of ferroptosis in early AM cell death remains inadequately defined, and its induction during...
Galectin-3 recruitment at the Mycobacterium tuberculosis-containing phagosome is critical in macrophage but dispensable in epithelial cells
Mycobacterium tuberculosis (Mtb) virulence relies in part on its ability to induce phagosomal membrane rupture, enabling bacterial access to the host cell cytosol. This process is largely mediated by the ESX{middle dot}1 secretion system, which is present in Mtb but absent from the vaccine strain BCG. Galectin{middle dot}3 (Gal3), a {beta}{middle dot}galactoside{middle dot}binding lectin, is recruited to damaged endomembranes and functions as a cytosolic sensor of membrane disruption.
Inorganic sulfate transport by the Mycobacterium tuberculosis PE22/PPE36 complex
Mycobacterium tuberculosis (Mtb) encodes two multigene families with 169 members that are exclusive to mycobacteria, the pe and ppe genes. These genes have unusual sequences including low-complexity repeat regions, but their functions and whether they share a common function have long been unclear. Recently, several members of the pe/ppe family were shown to transport nutrients across the outer Mtb membrane, a role for which no other proteins have yet been identified.
Researchers discover how to turn one germ's drug resistance into an Achilles' heel
Researchers discover how to turn one germ's drug resistance into an Achilles' heel Lisa Lock Scientific Editor Andrew Zinin Lead Editor Decades of reliance on the antibiotic rifampicin have fueled the rise of drug-resistant Mycobacterium tuberculosis (Mtb). But as the bacterium mutates to protect itself from the drug, it also creates new weak points that other therapies could exploit. Now, a new study published in Nature Microbiology shows that the most common rifampicin-resistance mutation...
A Crash Course in Mountain Bike Suspension (2026)
The trouble with being an aging mountain biker is that while my skills may marginally improve, the rocks don’t get any softer with every passing year. I’ve come to accept, for example, that I’m never going to clean the Teacup Trail in Sedona when riding from the west side of town over to the fun, mellow trails like Adobe Jack around Soldier Pass. But I stupidly keep trying, broken bones be damned, because what is also true: With every passing year, bike suspension keeps getting better.
Trans-identifying cyclist wins two Oregon women’s races by combined 48 minutes under OBRA rules
A trans-identifying biological male cyclist won two Oregon women’s mountain bike races in an eight-day span, including one by more than 36 minutes. Chloë Spritz won the Elite Women division at Silver Falls XC in Silver Falls State Park on May 16, according to official results posted by the Oregon Bicycle Racing Association. Spritz finished in 2:16:37.