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Scaffold, Not Vocabulary? A Controlled, Two-Tier, Pre-Registered Study of a Popperian Code-Generation Skill
arXiv:2606.06454v1 Announce Type: new Abstract: Large language models increasingly write, review, and judge code, and a fast-growing practice equips them with prompt 'skills' that ask the model to reason like a scientist. A prominent example tells the model to act as a Popperian falsificationist, and such skills are reported to improve generated code.
Unpredictable Safety: Domain-Dependent Compliance and the Transparency Gap in Open-Weight LLMs
Announce Type: new Abstract: We present a systematic study of domain-dependent safety behavior in open-weight LLMs: 7 standardized experiments across 7 ethical domains, testing 5 models (12B--70B) in 4,200 interactions with dual-judge validation. Using a dual-condition methodology, each scenario tested in both an analytical framing (identify the harm) and an operational framing (help commit the harm), we find compliance rates vary from 14.7% (human trafficking) to 85.7% (surveillance...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Every Byte Matters
Every byte matters Published 2026-06-01 on Farid Zakaria's Blog I have spent a large portion of my career working in Java. In that time, you get used to huge classes. Just add a new method and field to the class.
Restartable Sequences
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Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.
The Frame Problem
The Frame Problem To most AI researchers, the frame problem is the challenge of representing the effects of action in logic without having to represent explicitly a large number of intuitively obvious non-effects. But to many philosophers, the AI researchers' frame problem is suggestive of wider epistemological issues. Is it possible, in principle, to limit the scope of the reasoning required to derive the consequences of an action?