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Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Restartable Sequences
May 31st, 2026 @ justine's web page The best kept secret at the frontier of system programming right now is the Linux 4.18+ (c. 2018) concept of restartable sequences or rseq for short. They allow you to create thread-safe data structures without locks or atomics which scale to microprocessors with many cores. It's currently only possible to use rseq on Linux using handwritten assembly code.
Bill aims to end H-1B route to Green Cards & cut OPT: What the new act proposes
US lawmaker Chip Roy has introduced a bill aimed to overhaul the H-1B hiring programme titled “American White-Collar Worker Jobs Act of 2026”. Among other changes, the bill seeks to end the use of H-1B visas as a pathway to permanent residency ( Green Card) and eliminates the Optional Practical Training (OPT) program to prioritize employment opportunities for American STEM professionals. Publishing an official release, the Republican lawmaker said that the proposed legislation "would reform...
On the Duke--Erd\H{o}s--R\"odl Problem at the One-Third Threshold
Announce Type: cross Abstract: Let $G$ be an $n$-vertex graph with $e(G)\ge n^2/ k$. We prove a self-contained internal short-cycle core theorem at the threshold $k\le n^{1/3}$: the graph $G$ contains a subgraph $H_6$ with $\Omega(n^2/ k^3)$ edges in which every two distinct edges lie together on a cycle of length at most $6$ contained in $H_6$, and a subgraph $H_8$ with $\Omega(n^2/k^2)$ edges in which every two distinct edges lie together on a cycle of length at most $8$ contained in...
When Does Delegation Beat Majority? A Delegation-Based Aggregator for Multi-Sample LLM Inference
arXiv:2606.08098v1 Announce Type: new Abstract: Majority voting over sampled answers is the dominant unsupervised aggregator for multi-sample LLM inference. We show that piping the signals every sample carries into a delegation-based aggregator (Propagational Proxy Voting, PPV) yields an unsupervised consensus rule that beats majority on MMLU-Pro by +1.5 pp overall and +2.24 pp on the non-trivial subset (paired McNemar p ~ 1.0e-14, n = 8,099).
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
On graph products and multi-word-representability
arXiv:2603.29629v3 Announce Type: replace-cross Abstract: The multi-word-representation number $\mu(G)$ of a graph $G$ is the minimum number of word-representable graphs whose union is $G$. We study the behavior of $\mu$ under four standard graph products: the lexicographic, Cartesian, rooted, and corona products.
On graph products and multi-word-representability
arXiv:2603.29629v4 Announce Type: replace-cross Abstract: The multi-word-representation number $\mu(G)$ of a graph $G$ is the minimum number of word-representable graphs whose union is $G$. We study the behavior of $\mu$ under six standard graph products: the lexicographic, Cartesian, rooted, corona, tensor, and strong products. For the Cartesian and rooted products, we show that $\mu(G_1 \square G_2)=\mu(G_1 \diamond G_2)=\max\{\mu(G_1),\mu(G_2)\}$. For the corona product, we prove that...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.