NEFA

Adenosine A2A and A2B receptor signaling in neurons promotes glucose and fatty acid release in the postprandial state

Adenosine is a widely distributed signaling molecule whose levels rise during conditions of metabolic stress, hypoxia, or inflammation. Adenosine is a homeostatic regulator of neuronal, cardiovascular, immune, and metabolic functions through activation of adenosine receptors. Here, we show that administration of adenosine rapidly elicits an immediate and pronounced excursion of glucose and non-esterified fatty acids (NEFA) in mice refed for four hours but is greatly attenuated in fasted mice.