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In Vitro Efficacy of Paclitaxel-loaded PLGA Nanoformulations for Lung Cancer Treatment Demonstrated by Label-free Multiphoton-Fluorescence Lifetime Imaging Microscopy
Lung cancer remains the leading cause of cancer-related mortality, and despite its limited efficacy, and low specificity, chemotherapy is still commonly used as a first-line treatment. Herein, we prepare and characterize poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) for the use as a non-targeted nanocarrier drug delivery system for the chemotherapeutic drug, paclitaxel (PTX). Drug loading capability, mono-dispersity, zeta potential, morphology, and drug release profile were...
New health risks emerge as Europe’s drug market grows more complex, EU agency warns
Europe’s drug market is growing more complex, with potent opioids, stronger cannabis and new substances raising health risks, the EU agency warns. New health risks, rapidly evolving and increasingly complex drug markets - this is the warning issued on Tuesday by the European Union Drugs Agency. Its annual report, based on data from 27 EU member states as well as Turkey and Norway, highlights concerns not only about the availability of substances but also their growing variety,...