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Immune context unmasks regulatory effects of Neanderthal and Denisovan introgression

Neanderthal and Denisovan introgression have left a pervasive footprint in the human genome, yet its regulatory consequences remain poorly understood. Here we use a massively parallel reporter assay to characterize the cis-regulatory activity of 4,161 high-frequency introgressed variants across respiratory (A549), hepatic (HepG2), and hematopoietic (K562) cells exposed to immune and infectious stimuli. We find that ~18% of variants show differential activity between archaic and modern...

bioRxiv 9d ago

Recent analysis shows Neanderthals may have been first dentists in recorded history

One of the most dreaded terms in dentistry is “root canal,” but at least we get to enjoy the perks of modern medicine. Now, imagine enduring that painful process nearly 60,000 years ago. An international team of scientists believes they have found evidence that Neanderthals, the closest relatives of modern humans, deliberately drilled a hole in a lower molar tooth to remove infected tissue.

South China Morning Post 11d ago

Neanderthals treated a dental cavity by drilling into the tooth

A Neanderthal tooth shows clear signs of human intervention to treat bacterial decay, showing that the earliest dentistry began at least 59,000 years ago

New Scientist 28d ago

Neanderthal 'kneeprint' found next to mysterious stalagmite circle

An impression made in clay around 175,000 years ago could be a kneeprint left by one of the builders of a strange stalagmite circle found deep inside Bruniquel cave in south-west France

New Scientist 33d ago

If I had a hammer... it might actually be a rhino tooth

One way archaeologists learn how ancient people, including Neanderthals, did things is to attempt to do those things themselves, a process called experimental archaeology. Normally, that involves making stone tools, butchering deer, or distilling birch tar. But in a new study, it meant doing very destructive things to teeth from one of the world’s most carefully protected animals.

Ars Technica 8d ago

If I had a hammer... it might actually be a rhino tooth

One way archaeologists learn how ancient people, including Neanderthals, did things is to attempt to do those things themselves, a process called experimental archaeology. Normally, that involves making stone tools, butchering deer, or distilling birch tar. But in a new study, it meant doing very destructive things to teeth from one of the world’s most carefully protected animals.

Ars Technica Science 8d ago

Europe's aversion to eating insects may have deep ecological and evolutionary roots

Europe's aversion to eating insects may have deep ecological and evolutionary roots Sadie Harley Scientific Editor Robert Egan Associate Editor In recent years, human population growth, coupled with the climate crisis, environmental pressures, and current production and consumption patterns, has driven the search for alternative food sources. With 1,611 insect species listed as edible, organizations such as the Food and Agriculture Organization of the United Nations (FAO) have proposed...

Phys.org 5d ago

Alice Roberts: 'We are fundamentally, at the end of the day, animals'

Physically, Homo sapiens is not that special in the animal world. But the species has discovered ways of finding food and beating the odds of survival in every habitat from jungle to Arctic wasteland. It has also come to obsess Alice Roberts, who started off in medicine, becoming a surgeon and an anatomist.

New Scientist 7d ago

What really happened when ancient humans migrated out of Africa

This is an extract from Our Human Story, our newsletter about the revolution in archaeology. Sign up to receive it in your inbox every month. The great out-of-Africa migration is one of the canonical events in the human evolutionary story.

New Scientist 2d ago

Thirty years at El Mirón cave uncover 40,000 years of Iberian prehistory

Thirty years at El Mirón cave uncover 40,000 years of Iberian prehistory Lisa Lock Scientific Editor Robert Egan Associate Editor For the past three decades, a team of archaeologists have been uncovering some of the field's most recent monumental discoveries, relying on gut instinct, persistent hard work, and cutting-edge methods and technologies. The El Mirón Cave excavation project has been a long-term commitment for the lead researchers, fueled by each new discovery and a continued...

Phys.org 9d ago