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Some drugs 'fail' because of unrealistic testing conditions, scientists discover
Some drugs 'fail' because of unrealistic testing conditions, scientists discover Sadie Harley Scientific Editor Robert Egan Associate Editor A drug once dismissed as ineffective suddenly worked—when scientists tested it under more realistic conditions that mimic the human body. In this surprising new discovery, Northwestern University scientists uncovered a hidden rule of drug behavior. A medicine's effectiveness can change dramatically depending on the conditions inside our cells.
Milky Way black hole's missing wind finally found after a half-century-long search
Milky Way black hole's missing wind finally found after a half-century-long search Sadie Harley Scientific Editor Robert Egan Associate Editor After more than 50 years of searching, astrophysicists at Northwestern University have finally discovered evidence of a powerful wind blowing from the Milky Way's central supermassive black hole, Sagittarius A* (Sgr A*). According to theoretical physics and a long-accepted understanding of galaxies' evolution, as black holes consume materials, they...
New Velociraptor cousin was a '4-winged' dragon that hunted prey from the trees of ancient China, fossil find hints
New Velociraptor cousin was a '4-winged' dragon that hunted prey from the trees of ancient China, fossil find hints A new microraptor from Cretaceous China likely preyed on ancient birds. A newly discovered feathered dinosaur with four wing-like limbs may have prowled the lakeside forests of what is now northwestern China, gliding between trees like a flying squirrel and snatching some of the earliest birds out of the Cretaceous sky. The predator, named Jian changmaensis, was a close cousin...
Memory decline after menopause linked to loss of estrogen production in brain
A largely overlooked space between cells in women’s brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study. Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Scientists have long theorized that the loss of estrogen after menopause may reduce the brain’s natural protection against memory loss and...
Overlooked DNA structures help organize the genome
Overlooked DNA structures help organize the genome Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published in the Proceedings of the National Academy of Sciences. The study revealed that G-quadruplexes (G4s)—four-stranded DNA structures—directly interact with a key genome-organizing protein...
Red stripes declared U.K.’s oldest art after being dismissed as a natural phenomenon
LONDON — Dismissed as a natural phenomenon for more than a century, red stripes on a rock in Wales have been found to be the oldest known prehistoric art in Britain and northwestern Europe — created by human fingers 17,100 years ago, according to new research. An international team of scientists revisited Bacon Hole, a cave near Mumbles in South Wales, to re-examine the series of red-pigmented horizontal stripes on a panel first discovered there in 1912. The markings were initially...
Novel synthetic biomolecule degrades disease-related proteins
Novel synthetic biomolecule degrades disease-related proteins Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study published in Nature Communications. Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical...
Newfound velociraptor cousin probably glided on four 'wings' and hunted early birds
Newfound velociraptor cousin probably glided on four 'wings' and hunted early birds Gaby Clark Scientific Editor Robert Egan Associate Editor A fossil bed in northwestern China is littered with the remains of hundreds of prehistoric birds—including some whose broken bones were crushed into pellets, similar to those coughed up by modern owls. For years, scientists guessed that a larger predatory animal must have hunted these ancient birds, but they never found direct fossil evidence of this...
Chinese Velociraptor cousin had a taste for birds
Chinese Velociraptor cousin had a taste for birds WASHINGTON: About 120 million years ago in what is now northwestern China, many kinds of birds flocked to a lakeside ecosystem. This dense avian population would have offered a smorgasbord for a small and opportunistic carnivorous dinosaur.
Chinese homeowner buys 34th-floor flat in 32-storey building, gets no compensation
A Chinese man bought a flat on the 34th floor of a newly developed building only to be told four years later that the building only had 32 floors. The man, surnamed Shen, from northwestern China’s Shaanxi province, bought a new-build flat in a village near the provincial capital city Xian in 2013. He bought a 90-square-metre unit on the 34th floor of a building which cost 2,646 yuan (US$400) per square metre.