Novo

Novo and Lilly are competing to win the GLP-1 pill market as they prepare for Medicare coverage

Novo Nordisk and Eli Lilly took their GLP-1 pill battle to the preeminent obesity meeting this weekend as they prepare for the next sea change in how patients receive their drugs. Novo Nordisk on Sunday announced that prescriptions of the Wegovy pill have topped 3 million since it entered the U.S. market about five months ago. The Danish drugmaker's CEO Mike Doustdar celebrated the milestone, saying in an interview with CNBC that Novo was able to accelerate prescriptions even as Lilly...

Novo Nordisk rolls out Wegovy pill in the UAE — its first market outside the U.S.

Novo Nordisk is launching its weight loss pill Wegovy in the United Arab Emirates, the Danish drugmaker said Wednesday, marking its first launch outside the U.S. market. Novo's approach will be guided by patient demand, the readiness of healthcare professionals, and the strength of healthcare and telehealth infrastructure, said Emil Kongshøj Larsen, executive vice president, International Operations. "The UAE has demonstrated strong momentum across all of these areas, and we look forward to...

Ultra-low biomass sequencing workflow (LBV-Seq) enables de novo metagenomic reconstruction of DNA and RNA viral genomes

Genome-resolved virome analysis remains inaccessible for many samples, including those with clinical relevance, because viral nucleic acid recovered after enrichment is often too scarce to support de novo genome assembly. As a result, many analyses are limited to sparse read-level detection, which cannot recover divergent viruses, resolve strains, or interpret gene-level variation. Here, we developed Low Biomass Viral Sequencing (LBV-Seq), a workflow that couples low-input viral sample...

De novo mutation of an RNA virus is increased in the presence of engineered synonymous mutations that disrupt RNA structural elements

Using a combination of methods including selective 2?-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq), a complete RNA structure map of the cucumber mosaic virus (CMV) RNA 3 segment was mapped (Watters et al. (2018) Nucleic Acids Research 46, 2573?2584). To explore the effect of structural perturbations on genomic stability, infectious mutants were engineered to contain changes in one of four open reading frame (ORF) stem-loop (SL) structures SL1362, SL1439, SL1745 and...

Author Correction: De novo design of quasisymmetric two-component protein cages

Correction to: Nature https://doi.org/10.1038/s41586-026-10464-0 Published online 20 May 2026 In the version of the article initially published, David Chmielewski’s surname appeared incorrectly (as Chemielewski) and has now been corrected in the HTML and PDF versions of the article. Author information Authors and Affiliations Corresponding authors Rights and permissions About this article Cite this article Wang, S., Xie, Y., Chmielewski, D. et al.

De novo design of miniproteins targeting GPCRs

De novo design of quasisymmetric two-component protein cages

De novo molecular generation with optical property preconditioning at the token level

Announce Type: new Abstract: Designing OLED molecules with targeted optical properties remains challenging due to the scarcity of high-quality data and the limited reliability of conditional control in generative models across chemical motifs. Here, we benchmark a token-conditioned autoregressive language model for OLED molecular generation in a realistic low-data regime. A GPT2 model is pretrained on large chemical corpora, augmented with discrete property tokens, and fine-tuned using...

FLOWR: Flow Matching for Structure-Aware De Novo, Interaction- and Fragment-Based Ligand Generation

arXiv:2504.10564v3 Announce Type: replace-cross Abstract: We introduce FLOWR, a novel structure-based framework for the generation and optimization of three-dimensional ligands. FLOWR integrates continuous and categorical flow matching with equivariant optimal transport, enhanced by an efficient protein pocket conditioning. Alongside FLOWR, we present SPINDR, a thoroughly curated dataset comprising ligand-pocket co-crystal complexes specifically designed to address existing data quality issues.

From Holo Pockets to Electron Density: GPT-style Drug Design with Density

arXiv:2605.08767v2 Announce Type: replace Abstract: Recent advances in generative modeling have enabled significant progress in structure-based drug design (SBDD). Existing methods typically condition molecule generation on empty binding pockets from holo complexes, overlooking informative components such as the filler (ligands and solvent). Here, we leverage low-resolution electron density (ED) derived from the filler as a physically grounded condition for \textit{de novo} drug design.