Nucleus
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Show HN: Nucleus – A security-hardened, Nix-native container runtime
Extremely lightweight, security-hardened, declarative container runtime for agents and production services Nucleus is a minimalist container runtime for Linux. It provides isolated execution environments using Linux kernel primitives without the overhead of traditional container runtimes. For production services, it is designed around a fully declarative model: Nix builds the root filesystem, the NixOS module declares the service, and Nucleus mounts a pinned, reproducible closure at runtime.
Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a Shank3-/- Autism Model
Social behavior deficits are a common symptom of neuropsychiatric disorders, including autism spectrum disorder (ASD), but there are limited pharmacological treatments for these symptoms. Understanding how neurons encode social information will give insight into identifying novel pharmacological targets to address this unmet need. SHANK3 encodes a postsynaptic scaffold protein and is a common risk gene for several neuropsychiatric disorders characterized by social deficits, including ASD.
A semi-classical study of muon-enhanced proton-boron-11 fusion
Announce Type: cross Abstract: A recent theoretical study has suggested that muons can enhance proton-boron-11 (p-$^{11}$B) reaction cross-section by several orders of magnitude in the low-energy regime. In this work, we investigate this reaction process using a semi-classical treatment, that is, a muon and a proton first form a muonic hydrogen atom p$\mu$, which subsequently collides with a $^{11}$B nucleus. During the collision, the p$\mu$ atom approaches the $^{11}$B nucleus and is then...
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features
Cancer arises from extensive genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To systematically chart cancer-intrinsic regulatory programs, we constructed a pan-cancer single-cell transcriptomic and epigenomic atlas encompassing 60 human cell lines representing 16 tissue origins and 20 cancer types, comprising 240,957 single-nucleus RNA-seq and 223,347 single-nucleus ATAC-seq profiles. Integrative analyses revealed extensive...
Demonstrating CBM Capabilities by $\Lambda$ Baryon Reconstruction in Ni+Ni Collisions with the mCBM Experiment at SIS18 of GSI/FAIR
Announce Type: new Abstract: The Compressed Baryonic Matter (CBM) experiment at the upcoming Facility for Antiproton and Ion Research (FAIR) is a high-rate fixed-target experiment designed to investigate nuclear matter at extreme baryon densities in relativistic nucleus-nucleus collisions. To enable high-statistics measurements of rare probes, CBM is designed to operate at event rates up to 10 MHz. This necessitates the development of fast and radiation-tolerant detectors, self-triggered...
Quantum shell structure reveals new rule for proton-neutron pairing inside nuclei
Quantum shell structure reveals new rule for proton-neutron pairing inside nuclei Sadie Harley Scientific Editor Robert Egan Associate Editor Nuclear physicists used a little magic in their latest experiment conducted at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility, and the result has revealed surprising new information about the behavior of protons and neutrons inside the atom's nucleus. Specifically, the research revealed another requirement that...
A nuclear clock based on $^{229}$Th
Announce Type: new Abstract: Atomic clocks have made time and frequency the most precisely measured quantities in physics, progressing from microwave standards that realize the SI second to optical clocks that now reach unprecedented levels of precision. A nuclear clock would shift the frequency reference from an electronic transition to the uniquely low-lying, laser-accessible isomeric transition in the $^{229}$Th nucleus, offering a route to compact, robust timekeeping and sensitive tests...
Nucleoporin1 maintains male germ unit organization and transport in Arabidopsis pollen tubes, likely through shaping nuclear morphology
The male germ unit (MGU) in Arabidopsis pollen is comprised of one vegetative nucleus (VN) and two sperm nuclei (SN). It is evolutionarily specialized to deliver immotile sperm nuclei to an ovule for fertilization. Despite some progress in research on MGU, its organization and transport remain only partially understood.
Molecular Basis of Histone H3 Reading and Writing by Legionella pneumophila SET Domain Lysine Methyltransferases
RomA and its highly conserved strain ortholog LegAS4 are SET and ankyrin domain-containing effector proteins of the intracellular bacterial pathogen Legionella pneumophila. These enzymes are secreted into host cells, where they translocate to the nucleus and methylate Lys14 in histone H3 (H3K14), a novel post-translation modification (PTM) that reprograms gene expression and promotes bacterial replication. To elucidate their H3K14 substrate specificity, we determined the crystal structures...
Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells
Chronic stress induces structural and functional changes in the brain, increasing susceptibility to major depressive disorder and other mental illnesses. Myelination deficits are a key pathological feature of stress-related disorders, yet the molecular mechanisms linking chronic stress to oligodendrocyte dysfunction remain poorly understood. Here, we used single-nucleus multiome sequencing to map gene expression and chromatin-accessibility remodeling in the hippocampus of mice exposed to...