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Related Articles from SNS
Scheduling in Queueing Systems with Uncertain and Evolving Holding Costs
arXiv:2505.21331v2 Announce Type: replace Abstract: In content moderation for social media platforms, the cost of delaying the review of a content is proportional to its view trajectory, which fluctuates and is apriori unknown. Motivated by such uncertain and evolving holding costs, we consider a queueing model where job states evolve based on a Markov chain with state-dependent instantaneous holding costs. We demonstrate that in the presence of such uncertain and evolving holding costs, the...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.