Osteopontin
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Related Articles from SNS
Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy
Background: Successful pregnancy requires substantial maternal cardiovascular adaptation, including expansion and remodelling of the uterine arteries to support increased nutrient flow to the fetus. Hypertension is associated with impaired uterine artery remodelling and increased risk of fetal growth restriction and other adverse outcomes, yet the mechanisms driving vascular dysfunction in hypertensive pregnancy remain incompletely understood. Osteopontin, a matricellular protein, is...
Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans
Background: Thoracic aortic aneurysm (TAA) is a life-threatening condition with an unpredictable lisk of rupture. Current clinical parameters have limited ability to accurately predict imminent rupture. Osteopontin (OPN) has been implicated in aortic aneurysm pathology, however, it role as a marker of imminent rupture remains.