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Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Relaxation Kernel, Spectral Dissipation, and Global Convergence of Blahut--Arimoto Dynamics
arXiv:2604.25106v3 Announce Type: replace Abstract: We develop a spectral theory for continuous- and discrete-time Blahut--Arimoto (BA) dynamics, centered on the relaxation kernel $ \G = \E_p[K^*_X \otimes K^*_X] $. Five main results are established. Along the continuous-time BA flow, the free energy satisfies the exact $ \chi^2 $-dissipation identity $ \dot F_\beta = -\D(q) $, where $ \D(q)=\chi^2(\T q \| q) $ is the Pearson $ \chi^2 $-divergence.
Harry's and Coterie owner Mammoth Brands has ambitions to be the next CPG giant
Mammoth Brands wants to take on traditional consumer packaged goods companies, armed with a portfolio of disruptors in the personal and baby care categories that have won over consumers and retailers alike. For the last decade, upstarts like those owned by Mammoth have challenged the relevance and longstanding dominance of legacy giants like Procter & Gamble, Unilever and Kimberly-Clark. The trend has also played out across packaged food and beverage companies, like Poppi and Olipop taking...
Biryani, secret marriage, divorce, murder: Twists and turns in Bengaluru child death
Bengaluru: Two months after six-year-old Vennela was found dead under suspicious circumstances, Kadugodi police have launched a murder investigation into the case. The child's mother, advocate P Priyanka, and her friend Mohan G Mahalingappa, a real estate developer, have been booked for murder. Mohan has been remanded to seven-day police custody, while Priyanka remains untraceable.
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.
Anomalous Autler-Townes Splitting in Resonant Multiphoton Ionization Driven by Bright Squeezed Vacuum
Announce Type: new Abstract: Bright squeezed vacuum (BSV) light has a vanishing mean optical electric field yet can strongly enhance strong-field nonlinear responses beyond the conventional semiclassical paradigm. Here we examine this scenario in the light-matter strong-coupling regime by investigating resonant multiphoton ionization of atoms driven by BSV, using a fully quantum treatment of both the electron and the field.
Sibley's Guard-Point Convexity Measure: A Perimeter Counterexample and a Dominance Bound
Announce Type: new Abstract: We study Sibley's guard-point convexity measure for simple polygons and compare it with the exterior and perimeter convexity measures. We prove the exterior inequality G(F) <= E(F) and disprove the pointwise perimeter inequality G(F)
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Amplified Arctic iceberg traffic reshapes benthic biodiversity
Abstract The Arctic is undergoing rapid warming, resulting in retreating sea ice and glaciers1, yet how cryospheric changes propagate into the deep ocean remains poorly understood2. Here we identify a climate-driven mechanism linking accelerating glacier disintegration to an increase in deep-sea hard-bottom habitats far beyond calving fronts. Seafloor observations in Fram Strait show a localized increase in the density and patchiness of dropstones delivered by debris-laden icebergs.