P.J Evans
No mentions found
This entity hasn't been tracked yet, or Iris is still building its knowledge base.
Related Articles from SNS
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Amplified Arctic iceberg traffic reshapes benthic biodiversity
Abstract The Arctic is undergoing rapid warming, resulting in retreating sea ice and glaciers1, yet how cryospheric changes propagate into the deep ocean remains poorly understood2. Here we identify a climate-driven mechanism linking accelerating glacier disintegration to an increase in deep-sea hard-bottom habitats far beyond calving fronts. Seafloor observations in Fram Strait show a localized increase in the density and patchiness of dropstones delivered by debris-laden icebergs.
Gleam v1.17.0 Released
Gleam is a type safe and scalable language for the Erlang virtual machine and JavaScript runtimes. Today Gleam v1.17.0 has been published. But first: the first videos from the first ever all-Gleam conference have been released!
Alpine Linux 3.24.0 Released
Released We are pleased to announce the release of Alpine Linux 3.24.0, the first release in the v3.24 stable series. Highlights Significant changes Python setuptools 82.0.0 removed pkg_resources py3-setuptools has been upgraded to 82.0.0, which removed the deprecated pkg_resources module. Projects that still depend on it will no longer work and should migrate to its successors.