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Related Articles from SNS
Differential Sensitivity of HSV-1 and PRV to IFN-{lambda} Reveals a Neuron-Specific Antiviral Role for RSAD2
Alpha herpesviruses (-HV) initially infect mucosal epithelial cells and subsequently establish lifelong latency in the peripheral nervous system (PNS). Herpes simplex virus-1 (HSV-1), a human pathogen persisting in the majority of the adult population, shares neuroinvasive properties with Pseudorabies virus (PRV), a swine -HV, commonly used as a model -HV. Utilizing primary peripheral neuronal cultures, we previously showed that IFN-{lambda} pre-treatment significantly reduced PRV yield.
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology
Neural circuit wiring requires a remarkable level of precision, as thousands of neurons generate millions of synapses in distinct configurations. While neural circuits are known to be shaped by both neural birth timing and multiple classes of guidance molecules, the relationship between the two and how they coordinate circuit assembly has yet to be evaluated. Leveraging the well-defined stem cell lineages of the Drosophila embryonic nerve cord, we investigate how Roundabout (Robo) guidance...