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Potential economic impact of future Smart Data use cases
Potential economic impact of future Smart Data use cases Quantitative research assessing the potential social net present value and GDP impacts of 5 Smart Data use cases over a 15-year period. The Department for Business and Trade (DBT) commissioned the Public Service Consultants (PSC) to complete research that assessed the social net present value and gross domestic product (GDP) impacts of 5 Smart Data use cases over a 15-year period (2028 to 2043). The report includes the findings from a...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Learning to replenish: A hybrid deep reinforcement learning for dynamic inventory management in the pharmaceutical supply chains
arXiv:2606.06201v1 Announce Type: new Abstract: Pharmaceutical supply chains (PSCs) struggle with inventory management (IM) due to unpredictable demand patterns and variable lead times associated with restocking. This complexity is further compounded by the finite shelf lives of pharmaceutical products, which necessitate a delicate balance between adequate stock and minimal waste. These intertwined factors create a complex optimization problem that requires sophisticated inventory strategies...
Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Reduced Neuroaxonal Integrity
Despite sustained viral suppression with effective antiretroviral therapy (ART), neuroaxonal integrity persist in a subset of people with HIV-1 (PWH). We investigated whether interferon (IFN)-inducible APOBEC3-associated mutational signatures, reflected by premature stop codons (PSCs), and reservoir-associated drug resistance mutations (RS-DRMs) within transcriptionally active HIV-1 reservoirs influence neuroaxonal integrity in fully virally suppressed individuals. Peripheral CD4 T cells...