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A Pan-pangenome illuminates complex structural variation and selection in humans, chimpanzees, and bonobos
Complete, haplotype-resolved genome assemblies have provided unprecedented insight into the evolution of structurally complex, rapidly evolving regions of human genomes; however, population-scale pangenome resources of our closest relatives, chimpanzees and bonobos (genus, Pan), are necessary to ascertain the origins and evolutionary context of these loci. Here, we sequence and assemble 58 haplotypes from four distinct Pan clades to high contiguity (median contig NG50=54 Mb), including eight...
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features
Cancer arises from extensive genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To systematically chart cancer-intrinsic regulatory programs, we constructed a pan-cancer single-cell transcriptomic and epigenomic atlas encompassing 60 human cell lines representing 16 tissue origins and 20 cancer types, comprising 240,957 single-nucleus RNA-seq and 223,347 single-nucleus ATAC-seq profiles. Integrative analyses revealed extensive...
Rep. Kevin Kiley, Independent, to Face Richard Pan in California House Race
Representative Kevin Kiley and Richard Pan will compete in November.
Meera Sodha’s vegetarian recipe for crispy one-pan spaghetti with gochujang and mozzarella |. Meera Sodha recipes
Meera Sodha has adapted the traditional Italian spaghetti all'assassina into a fusion dish featuring gochujang and mozzarella. The recipe involves cooking the spaghetti in a pan, allowing the edges to crisp up in a risotto-style preparation. This results in a unique, spicy, and crispy pasta dish.
Le Creuset Summer Sale: Save $170 on Dutch ovens and up to 40% on nonstick pans and more
Le Creuset is starting the month off with some highly coveted deals on Dutch ovens, stainless steel cookware and more. The brand is having its Summer Cookware Event and putting their popular signature Dutch oven, stainless steel collection and their nonstick cookware lines on sale, with discounts up to 40% off. It’s a great opportunity to save on kitchen essentials, even if you may be cooking less during the summer months.
A Pan-Cancer Multi-Omic SuperLearner for Regulated Cell Death Survival Topologies
Introduction: Regulated cell death (RCD) pathways profoundly influence tumor progression and immune modulation. In prior work, we constructed a comprehensive database mapping 25 forms of RCD across seven multi-omic layers encompassing 33 tumor types (CancerRCDShiny). Despite their robust ability to identify risk populations, translating these prognostic signatures into personalized clinical workflows requires a shift from generalized cohort stratification to individualized risk mapping.
Aliens, Pan-Africanism and Olivia Rodrigo: What to see, do or hear this week in Europe
Steven Spielberg's 'Disclosure Day' beams into the box office while Olivia Rodrigo sings about love making us crazy. Here's what to look out for this week. Hello, and welcome back for another round of cool things to do, see and hear this week.
Loss of tissue specificity and recurrent pan-cancer activation define a conserved oncogenic microRNA class
MicroRNAs (miRNAs) act as crucial post-transcriptional regulators of large gene networks, and their aberrant expression drives key oncogenic processes such as epithelial-mesenchymal transition (EMT), angiogenesis, immune evasion, and metastasis. Oncogenic miRNAs that lose tissue specificity during malignant transformation represent promising therapeutic targets, as their restricted expression in healthy organs could minimize off-target effects. To identify these candidates, this study...
Jack White’s panned exhibition: Which musicians found success in fine art?
Jack White’s debut exhibition has divided opinion. Here’s how other music icons fared in the court of public opinion and the eyes of critics.
CrowdStrike’s stock falls as investors find more reason to pan cybersecurity earnings
Like Palo Alto Networks before it, CrowdStrike beats financial expectations but sees its stock get punished