Patch Dynamics Scheme
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A Generalised Curvilinear Coordinate system-based Patch Dynamics Scheme in Equation-free Multiscale Modelling
arXiv:2405.08764v2 Announce Type: replace Abstract: The patch dynamics scheme in equation-free multiscale modelling has the potential to efficiently predict the macroscopic behaviours by simulating the microscale problem in a fraction of the space-time domain. The patch dynamics schemes developed so far are mainly on rectangular domains with uniform grids and uniform rectangular patches. In real-life problems, the geometry of the domain is not regular or simple, where rectangular and uniform...
TiWeaver: Unified Temporal Dynamics Modeling via Contextual Patching
arXiv:2606.03121v1 Announce Type: new Abstract: Multivariate time series forecasting plays a critical role in real-world applications, including weather prediction, stock analysis, and health monitoring. Due to the diversity of data sources, time series exhibit diverse temporal dynamics, often accompanied by various irregularities such as missing values and non-uniform sampling frequencies. Such irregularities lead to complex and asynchronous temporal dependencies across channels.
Diffusion Image Generation with Explicit Modeling of Data Manifold Geometry
Announce Type: replace Abstract: Image generative models aim to sample data points from the underlying data manifold, a task that requires learning and decoding a dense, low-dimensional, and compact parameterization space. To achieve this, we propose the Data Manifold-aware Image diffusioN moDel (MIND), a novel framework that explicitly models manifold geometry by integrating discrete patch tokenization into the score function of a continuous diffusion model. This approach successfully...
DPM++: Dynamic Masked Metric Learning for Occluded Person Re-identification
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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).