Perfusion Estimation
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Adjoint-based Perfusion Estimation from Dynamic Contrast-Enhanced Ultrasound: Advection-Diffusion and Two-Compartment Models
Announce Type: new Abstract: Tumor perfusion and vascular properties are important determinants of a cancer's response to therapy. In this paper, we discuss the estimation of spatially varying blood flow velocities and perfusion parameters from time-resolved contrast agent concentration data. We compare a standard parabolic advection-diffusion model against a two-compartment model governed by a coupled system of hyperbolic advection-reaction equations, which is physiologically more sound.