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Deciphering and Improving Human Homogentisate 1,2-Dioxygenase Function Through Knowledge Gaining Directed Evolution: Implications for Alkaptonuria

Human homogentisate 1,2-dioxygenase (HGD) catalyses the oxidative cleavage of homogentisic acid (HGA) to maleylacetoacetate (MAA), a key step in tyrosine degradation. Loss of HGD activity causes alkaptonuria (AKU), a rare inherited metabolic disorder characterized by toxic HGA accumulation. Current therapy with nitisinone lowers HGA levels but does not restore HGD function, motivating further investigation of HGD structure-function relationships.

bioRxiv 7d ago

Sources: QB Brissett to report for Cards minicamp

TEMPE, Ariz. -- Cardinals quarterback Jacoby Brissett will report for Arizona's mandatory minicamp this week, sources told ESPN, after holding out for all of the team's offseason program while he awaits a reworked contract for this season Brissett was at risk of being fined a total of $107,911 if he didn't show up, according to the NFL's collective bargaining agreement. Brissett missed the entirety of Arizona's Phase 1 and Phase 2 as well as all three of the Cardinals' OTAs. The Cardinals'...

ESPN 2d ago

Klein--Gordon and Dirac Oscillators with an Apparent Mass Induced by the Momentum-Space Dual of the Fock--Lorentz Transformations

arXiv:2606.05226v1 Announce Type: new Abstract: We propose a controlled momentum-space dual of the Fock--Lorentz (FL) transformations and use it to derive a deformed relativistic mass shell. Restricting the FL conformal factor to the cosmological-frame world line $\vx=0$, the invariant relation takes the form $(E^{2}-\vp^{2}c^{2})(1+ct/R)^{2}=m_{0}^{2}c^{4}$, which is equivalent to the standard special-relativistic dispersion law with a time-dependent apparent mass $\mapp(t)=m_{0}/(1+ct/R)$....

arXiv Physics 5d ago

DuetServe: Harmonizing Prefill and Decode for LLM Serving via Adaptive GPU Multiplexing

arXiv:2511.04791v2 Announce Type: replace Abstract: Modern LLM serving systems must sustain high throughput while meeting strict latency SLOs across two distinct inference phases: compute-intensive prefill and memory-bound decode phases. Existing approaches either (1) aggregate both phases on shared GPUs, leading to interference between prefill and decode phases, which degrades Time-Between-Tokens (TBT); or (2) disaggregate the two phases across GPUs, improving latency but wasting resources...

arXiv CS 8d ago

A universal complementarity identity for polarized double-slit interferometry

arXiv:2604.18760v2 Announce Type: replace-cross Abstract: An exact identity is established among four experimentally accessible quantities in polarized double-slit interferometry: the phase-reference-dependent in-phase and quadrature components $V_A$ and $V_N$ of fringe visibility, the path predictability $\mathcal{P}$, and the mixedness $\mathcal{I}$ of the reduced path state satisfy $V_A^2+V_N^2+\mathcal{P}^2+\mathcal{I}^2=1$. The identity is an algebraic consequence of positivity and...

arXiv Physics 9d ago

Light-induced quantum friction of carbon nanotubes in water

Abstract Friction slows down moving objects at both macroscopic and microscopic scales1. At the electronic level, quantum friction describes direct transfer of momentum between a liquid and the electrons of a solid2. Owing to its microscopic nature, this phenomenon remains experimentally challenging to capture3.

Nature 17h ago

Domain Adaptation and Reasoning Frameworks in Language Models: A Controlled Experiment with Historical Cosmology

arXiv:2605.30415v1 Announce Type: new Abstract: We investigate how domain adaptation reshapes explanatory behavior in language models using historical cosmology as a controlled setting. In Phase 1, we train a small language model from scratch on a pre-Copernican corpus from which explicit heliocentric references were removed, and evaluate whether Earth-motion or heliocentric continuations nevertheless emerge. In Phase 2, we fine-tune a larger pretrained model using QLoRA on the same corpus...

arXiv CS 9d ago

Backpressure is all you need

Backpressure is all you need There are two obvious ways to use coding agents. The first is to let the LLM run unattended and hope the repository survives. This is fast, exciting, and stupid.

Hacker News 10d ago

Measurement of reactor neutrino oscillation with the first JUNO data

Abstract Neutrino oscillations (see refs. 1,2 and references therein), a quantum effect manifesting at macroscopic scales, are governed by lepton flavour mixing angles and neutrino mass-squared differences3 that are fundamental parameters of particle physics, representing phenomena beyond the Standard Model. Precision measurements of these parameters are essential for testing the completeness of the three-flavour framework, determining the mass ordering of neutrinos and probing possible new...

Nature 17h ago

Two-component exciton condensates in an electron–hole bilayer

Abstract Macroscopic quantum coherence emerges when bosons condense into a Bose–Einstein condensate (BEC)1,2,3,4,5. Excitons are a long-sought solid-state route to high-temperature BECs with strong interactions, electrical tunability and potentially multicomponent spinor order, but conclusive evidence for equilibrium condensation has remained elusive. Here we report evidence for two-component exciton BECs in MoSe2/hBN/WSe2 electron–hole bilayers6,7,8,9 by probing the spin–valley...

Nature 17h ago