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Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer
Therapeutic resistance remains a major challenge in advanced and recurrent endometrial cancer (EC). Aberrant NOTCH signaling has been associated with aggressive tumor behavior and therapeutic resistance across multiple malignancies, yet its therapeutic significance in EC remains incompletely defined. We investigated whether auranofin (AuR), a noncanonical modulator of NOTCH signaling through the transcriptional effector RBPJ, alters platinum responsiveness in EC models.
GPU Acceleration of Collinear and Noncollinear DFT Using a Numerical Atomic Orbital-Based DFT Code
new Abstract: We implement GPU acceleration of collinear and noncollinear density functional theory (DFT) calculations in the numerical atomic orbitals (NAOs) code OpenMX by offloading matrix multiplications and eigenvalue solves (plus selected auxiliary steps) to cuBLAS/cuSOLVER and OpenACC. Benchmarks on the Pegasus supercomputer (per node: a 48-core Intel Xeon Platinum 8468 CPU and one NVIDIA H100 GPU) compare GPU-accelerated and CPU-only runs under identical settings. For a 512-atom...
Goodbye, Norma Jeane: How Marilyn Monroe changed Hollywood
Goodbye, Norma Jeane: How Marilyn Monroe changed Hollywood May 31, 2026For decades,Marilyn Monroe's white dress billowing above a subway grate, red lips and platinum-blonde hair have represented the epitome of Hollywood glamour. The iconic scene from the movie "The Seven Year Itch" (1955) is perhaps one of the most famous moments in film history. Very few women of the 20th century achieved the iconic status Monroe did while simultaneously being ferociously judged for their appearance.
[Written Question] Fire and Rescue Services: Medals
Question by: Damien Egan Answering Body: Ministry of Housing, Communities and Local Government Question: To ask the Secretary of State for Housing, Communities and Local Government, what assessment he has made of the adequacy of the eligibility criteria applied to Fire Control staff for the award of the Platinum Jubilee Medal, Diamond Jubilee Medal, and Gold
Atomic reshuffle leads to record-breaking catalysts for hydrogen production
Researchers have discovered that atoms can be mixed, separated, and recombined within the same experiment, providing a pathway to a record-breaking catalyst for green hydrogen production. In their study, the team created nanoscale particles containing only a few dozen platinum and nickel atoms and observed unusual dynamic behavior in direct space and in real time. As the two metals separate from one another while maintaining an interface, they become highly active for electrochemical water...
The App Store is going to add subscription bundles soon
Later this year, you will be able to get bundled subscriptions for iPhone apps, as Apple announced it's expanding App Store bundles so they can include offers from different companies. It's similar to streaming video bundles that have combined offers for Apple TV and Peacock, but it also could put together subscriptions for completely different services, like Instagram Plus and Tinder Platinum. Another option on the way is Suites, "a set of subscriptions that aren't available standalone,...
Forget LASIK: Safer, cheaper vision correction without lasers or surgery
Researchers are developing a futuristic alternative to LASIK that reshapes the eye without lasers or incisions. Using mild electrical pulses and platinum contact lenses, they temporarily soften the cornea so it can be molded into a new shape. Early tests on rabbit eyes successfully corrected nearsightedness in about a minute while preserving the eye’s structure.
Randy Travis' health crisis began with 'congestion' and ended in a five-month hospital stay
Randy Travis' intense health journey started with a symptom of the common cold. During a recent interview with Fox News Digital while at The Nashville Palace — where a celebration took place on June 3 in honor of the 40th anniversary of his first album "Storms of Life," the 67-year-old and his wife, Mary Travis, spoke about a time in his life where he leaned on his faith the most, noting he initially went to the doctor after having issues with "congestion," but ended up finding something...
Ulta Promo Codes: Up to 50% Off in June 2026
At Ulta Beauty, you can stock up on skincare, makeup, and haircare, then head to the salon to get your brows shaped, your hair styled, and your ears pierced, all in a single visit. You’ll find brands like Dior, Estée Lauder, and Gucci alongside more affordable favorites and drugstore staples. Many locations house a Benefit Cosmetics BrowBar, so you can sample products and book an in-store brow service in the same visit.
Squarespace Promo Codes: 20% Off in June 2026
Squarespace helps small businesses and regular Joe Schmoes to get software help to build their own websites (for both personal and business), even including the commerce side of things with point of sale, inventory, and customer data features (both online or in person). In the age where literally everything is digitized and accessed through the World Wide Web, having an online presence is the most important thing you can do for your business or brand’s growth. Creating a website can be...