Progressive Loss
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Related Articles from SNS
Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis
Idiopathic pulmonary fibrosis (IPF) is characterized by failed alveolar epithelial repair and progressive fibrotic remodeling. Although aberrant reprogramming of alveolar type 2 (AT2) cells and accumulation of transitional AT2 states are increasing recognized as central features of IPF, the epithelial-intrinsic mechanisms that initiate these pathogenic states remain incompletely understood. Here, we identify mitochondrial transcription factor A (TFAM), a regulator of mitochondrial DNA...
GLP-1s appear to protect against cancer. Researchers are trying to figure out how
Recent studies suggest GLP-1s, the weight loss and diabetes drugs, may both prevent cancer and slow its progression. While weight loss is known to curb cancer risks, GLP-1s may act on other brain and metabolic pathways to prevent cancer.(Image credit: Michael Siluk)
Parents call for heel prick testing after son, 7, dies from degenerative disease
MLD is a rare metabolic disorder that leads to a progressive loss of physical and mental skills.
Parents call for heel prick testing after son, 7, dies from degenerative disease
MLD is a rare metabolic disorder that leads to a progressive loss of physical and mental skills.
'A heel prick test might have saved our seven-year-old son's life'
MLD is a rare metabolic disorder that leads to a progressive loss of physical and mental skills.
'A heel prick test might have saved our seven-year-old son's life'
MLD is a rare metabolic disorder that leads to a progressive loss of physical and mental skills.
Parents call for heel prick testing after son, 7, dies from degenerative disease
MLD is a rare metabolic disorder that leads to a progressive loss of physical and mental skills.
Preserving Plasticity in Continual Learning via Dynamical Isometry
new Abstract: Continual training of deep neural networks under non-stationarity often leads to a progressive loss of plasticity, eventually limiting further learning. We relate plasticity to the empirical Neural Tangent Kernel, and identify dynamical isometry (the condition that layer-wise Jacobian singular values remain close to one) as a key mechanism for preserving plasticity in continual learning. We revisit a class of networks that are almost-everywhere isometric while remaining...
Comprehensive characterization of skeletal muscle remodeling in hSOD1G93A mice reveals limited functional impact of systemic FOXO1 inhibition
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron (MN) loss, muscle atrophy and paralysis. Although traditionally considered a MN-specific disease, accumulating evidence supports a crucial contribution of skeletal muscle pathology to disease onset and progression. Except for specific mutations, to date there is no effective treatment for ALS.
T-SAR-JEPA: Self-Supervised Temporal Anomaly Detection in SAR Amplitude Stacks via Latent Prediction
arXiv:2606.05700v1 Announce Type: new Abstract: We present T-SAR-JEPA, a self-supervised framework for temporal anomaly detection in SAR amplitude stacks via latent prediction. A ViT-Base/16 encoder from SAR-JEPA is domain-adapted on 39,300 Capella patches using local masked reconstruction with gradient feature prediction. A temporal transformer with sinusoidal time encoding forecasts future latent states from K=7 acquisitions, with progressive unfreezing substantially reducing validation loss.