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Related Articles from SNS
Biological Reasoning-Informed Regression for Interpretable Regulatory DNA Activity Prediction
arXiv:2606.08147v1 Announce Type: cross Abstract: DNA cis-regulatory elements (CREs) such as enhancers control gene expression levels. Accurately predicting regulatory activity from DNA sequences is valuable but challenging, as it requires understanding complex biological regulatory processes. Existing methods typically regress activity scores from sequences in a black-box manner, limiting both interpretability and regression performance.