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Combined photon-proton modeling of radiation-induced brain imaging changes supports variability in proton relative biological effectiveness and increased periventricular radiosensitivity

arXiv:2604.10174v2 Announce Type: replace Abstract: Purpose: Recent proton-only investigations of radiation-induced contrast enhancements (RICE) in brain tumor patients indicated variability in proton relative biological effectiveness (RBE) and increased radiosensitivity of the periventricular region (PVR). Because RBE is defined relative to a reference radiation, these studies required assumptions on the photon dose-response relationship. This study aimed to validate proton RBE variability...

arXiv Physics 6d ago