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Sex and Alternative Splicing in Disease: a meta-analytic approach to identify interactions
How cell type, sex and disease interact and affect gene expression and splicing is an important, but complicated question. Visualizing and testing specific hypotheses around these complex interactions is an important first step to identifying molecular components underpinning complex disease. Using a meta-analytical framework, we develop an analytical path for identifying testable molecular hypotheses of complex interactions between splicing, sex, disease and cell type.
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Although spread of internalized Mtb from the initial infected alveolar macrophages (AMs) is a crucial determinant of infection outcomes, the role of cell death in facilitating this spread, and how it is regulated by Mtb remains poorly understood. Ferroptosis, a lipid peroxidation-mediated form of necrotic cell death, contributes to pathology during later stages of infection. However, the role of ferroptosis in early AM cell death remains inadequately defined, and its induction during...