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RankByGene: Gene-Guided Histopathology Representation Learning Through Cross-Modal Ranking Consistency

arXiv:2411.15076v3 Announce Type: replace-cross Abstract: Spatial transcriptomics (ST) provides essential spatial context by mapping gene expression within tissue, enabling detailed study of cellular heterogeneity and tissue organization. However, aligning ST data with histology images poses challenges due to inherent spatial distortions and modality-specific variations. Existing methods largely rely on direct alignment, which often fails to capture complex cross-modal relationships.

arXiv CS 8d ago