Rapid Determination of Drug
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Rapid Determination of Drug-to-Antibody Ratios in Antibody Drug Conjugates Using Ultrafast Microdroplet Digestion Technology
Accurate determination of drug to antibody ratios (DARs) is essential for the development, quality control, and performance evaluation of antibody drug conjugates (ADCs); yet conventional analytical approaches often require extensive sample preparation, long analysis time, and substantial sample consumption. The peak distribution of intact ADCs is highly complex due to inherent glycosylation heterogeneity and variable drug conjugation. By applying enzymatic digestion, ADC can be converted...
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
How I use AI to turn failed drugs into new medicines
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Fluorescent nanosensor detects key gut biomarker in minutes for faster testing
Fluorescent nanosensor detects key gut biomarker in minutes for faster testing Sadie Harley Scientific Editor Robert Egan Associate Editor A research collaboration has developed a novel fluorescent nanosensor capable of rapidly detecting indole-3-propionic acid (IPA), an emerging biomarker linked to gut health and disease. The breakthrough is described in the team's paper, "Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring," published in the journal...
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Programmable chemistry unlocks drugs only in target cells, aiming to cut side effects
Programmable chemistry unlocks drugs only in target cells, aiming to cut side effects Gaby Clark Scientific Editor Robert Egan Associate Editor Potent drugs like chemotherapy can be life-saving, but often with life-threatening side effects. Notably, they can be indiscriminate, killing both cancer cells and healthy cells in one swoop. Increasing a drug's on-target efficiency can reduce side effects and enable healthier outcomes for patients.
Muscle-boosting drug could help retain lean tissue when using weight-loss jabs
The Independent's journalism is supported by our readers. When you purchase through links on our site, we may earn commission. Muscle-boosting drug could help retain lean tissue when using weight-loss jabs
Weight loss jab users warned not to ignore 1 symptom affecting the eyes
Weight loss jab users warned not to ignore 1 symptom affecting the eyes Health officials have issued a warning to weight loss jab users after a rare eye condition was linked to a popular medication used by thousands Millions of people use weight loss and diabetes jabs every year, but health officials are warning patients to be alert to one potentially serious symptom that could affect their eyesight. The alert concerns medicines containing semaglutide, including Wegovy, Ozempic and Rybelsus....
The race against time to contain Ebola
Fighting the spread of Ebola virus in one of the world's 'most volatile' regions Fri 5 Jun 2026 at 6:07am Near the heart of the spreading Ebola outbreak, young mother Marléne is well aware of the potential danger. She's brought her two-month-old daughter, Deborah, to be vaccinated at a health facility in the eastern Democratic Republic of Congo. The north-eastern region of Ituri has so far seen more than 100 confirmed cases of the disease, with more in neighbouring North Kivu.