Rapid State Space Sampling
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Think Fast and Far: Long-Horizon Online POMDP Planning via Rapid State Sampling
Announce Type: new Abstract: Partially Observable Markov Decision Processes (POMDPs) are a general and principled framework for motion planning under uncertainty. Despite tremendous improvement in the scalability of POMDP solvers, long-horizon POMDPs remain difficult to solve. To alleviate the difficulty, this paper proposes a new approximate online POMDP solver, called Reference-Based Online POMDP Planning via Rapid State Space Sampling (ROP-RAS3).
A thalamus–brainstem attractor network drives history-biased decisions
Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...
Generalizable Multi-Task Learning for Wireless Networks Using Prompt Decision Transformers
arXiv:2606.04328v1 Announce Type: new Abstract: Future wireless networks demand rapid adaptation to highly heterogeneous environments and dynamic task configurations, necessitating a shift from conventional rule-based and optimization-driven radio resource management (RRM) toward artificial intelligence (AI)-driven RRM. AI-driven approaches can learn complex nonlinear relationships, generalize across diverse network conditions and enable real-time, scalable and autonomous decision-making....
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Amplified Arctic iceberg traffic reshapes benthic biodiversity
Abstract The Arctic is undergoing rapid warming, resulting in retreating sea ice and glaciers1, yet how cryospheric changes propagate into the deep ocean remains poorly understood2. Here we identify a climate-driven mechanism linking accelerating glacier disintegration to an increase in deep-sea hard-bottom habitats far beyond calving fronts. Seafloor observations in Fram Strait show a localized increase in the density and patchiness of dropstones delivered by debris-laden icebergs.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Should we store Mars samples on the moon to keep alien germs away from Earth?
Should we store Mars samples on the moon to keep alien germs away from Earth? "The moon may become humanity's first line of biological defense." A team of researchers is advocating to use the moon as a secure site for biocontainment of extraterrestrial samples, particularly those from Mars, but also from other potential worlds like Enceladus, a moon of Saturn.
How do you stop Ebola at the World Cup?
LOS ANGELES — When the United States, Canada and Mexico formally submitted their co-hosting bid to soccer governing body FIFA in 2018, they touted the safety of the region, noting “no major endemic infectious diseases across any of our Host Countries.” Now, as the three countries prepare to welcome one of the largest international gatherings around the globe since the Covid-19 pandemic, infectious diseases are front of mind. Of particular concern is an outbreak of...
How do you stop Ebola at the World Cup?
LOS ANGELES — When the United States, Canada and Mexico formally submitted their co-hosting bid to soccer governing body FIFA in 2018, they touted the safety of the region, noting “no major endemic infectious diseases across any of our Host Countries.” Now, as the three countries prepare to welcome one of the largest international gatherings around the globe since the Covid-19 pandemic, infectious diseases are front of mind. Of particular concern is an outbreak of Ebola that is...
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.