SIV

AZD5582 robustly reactivates latently infected cells and clears the majority of those reactivated from the SIV reservoir

AZD5582 (AZD) is a latency reversing agent used to support the "shock-and-kill" strategy in HIV-1 cure research. Previous studies in ART-suppressed rhesus macaques have shown that AZD can promote reactivation of latently infected cells, resulting in 2-3 log increases in on-ART viral load and significant reductions in SIV reservoir size over 5-10 doses. To quantify the impact of AZD on the reservoir, we developed an ensemble of mechanistic viral dynamic models and fit them to longitudinal...