Sanger Institute
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Related Articles from SNS
Why are sloths slow? It's in their DNA
It's in their DNA Lisa Lock Scientific Editor Robert Egan Associate Editor Sloths are the slowest mammals on the planet, but living in dense jungles has made them notoriously difficult to study. For the first time, scientists have now sequenced and analyzed the two-toed sloth genome and revealed the genetics behind its extremely slow metabolism. Building on work initiated at the Leibniz Institute for Zoo and Wildlife Research (IZW) in Berlin, Germany, researchers at the Wellcome Sanger...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.