Shared Scaffold
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BijectiveRemesh: Maintaining Bijective Mappings for Data Transfer Across Remeshed Manifolds
Announce Type: new Abstract: We introduce BijectiveRemesh, a robust algorithm for maintaining a continuous, bijective mapping across complex remeshing sequences on both 2D triangle surfaces and 3D tetrahedral meshes. Unlike traditional data transfer methods that rely on interpolation or projection, our approach constructs a mathematically rigorous composite map from the input mesh to the output mesh by chaining local bijective atlases defined for each primitive remeshing operation. Our...
Towards Cybersecurity SuperIntelligence (CSI): What's the best harness for cybersecurity?
arXiv:2605.28334v2 Announce Type: replace Abstract: What is the best harness for cybersecurity AI? Cybersecurity systems are converging on a single execution scaffold per agent, an iterative shell loop driven by a Large Language Model (LLM). However, scaffolds are not interchangeable, rarely interoperable, and no single scaffold dominates across all challenge types.
BareWave: Waveform-Native Flow-Matching Text-to-Speech
arXiv:2606.09048v1 Announce Type: cross Abstract: Removing intermediate representations and separately trained decoding stages has become an important direction in generative modeling. In text-to-speech, however, high-quality systems are still commonly built through an intermediate acoustic representation before waveform synthesis. In this work, we present BareWave, a fully waveform-native framework for direct text-to-wave generation in flow-matching TTS.
A functional amyloid scaffold shapes insect egg coats
Functional amyloids serve as structural scaffolds across biology, yet the molecular architecture and assembly principles of many remain unresolved. The lepidopteran egg coat, or chorion, presents a striking example: hundreds of paralogous proteins sharing a conserved central domain assemble into a mechanically resilient amyloid matrix essential for embryo protection. Here, combining evolutionary analysis of more than 500 sequences with cryo-electron microscopy and biophysical assays, we...
Do Larger Models Really Win in Drug Discovery? A Benchmark Assessment of Model Scaling in AI-Driven Molecular Property and Activity Prediction
Announce Type: replace Abstract: The rapid growth of molecular foundation models and large language models (LLMs) has encouraged a scale centred view of AI in drug discovery, in which larger pretrained models are expected to supersede compact cheminformatics models. We test this assumption across 26 ADME, toxicity and bioactivity endpoints, covering 165,541 endpoint level compound label records. The benchmark contains 78 endpoint and split entries evaluated under random, Murcko scaffold and...
The Speed of Prototyping in the Age of AI
Note: These are personal reflections on how my workflow has shifted over the past year, not a pitch for any tool. Your mileage will (and probably should) vary. A few years back I wrote about my love of throwaway prototypes; those little proof-of-concepts that exist purely to get an idea out of your head and into something tangible.
Overexpression of Eaf1, a subunit of the NuA4 lysine acetyl transferase complex, rescues growth defects in the budding yeast H3K36M oncohistone model via histone H4 tail acetylation
Histone proteins are critical for regulating functions that occur at DNA, such as gene expression. Certain mutations in histone genes were characterized to drive oncogenesis, termed oncohistones, and one of the first identified oncohistones is H3K36M. While humans have a high copy number of H3 genes, making genetic engineering in cell lines challenging, budding yeast only have two H3 genes. Additionally, histone H3 shares 90% sequence identity between budding yeast and humans, making it a...
Topology-Aware LLM-Driven Social Simulation: A Unified Framework for Efficient and Realistic Agent Dynamics
arXiv:2604.18011v2 Announce Type: replace Abstract: Social simulation is essential for understanding collective human behavior by modeling how individual interactions give rise to large-scale social dynamics. Recent advances in large language models (LLMs) have enabled multi-agent frameworks with human-like reasoning and communication capabilities. However, existing LLM-based simulations treat social networks as fixed communication scaffolds, failing to leverage the structural signals that...
Six people stabbed as Arsenal fans celebrate Premier League title at victory parade
Arsenal parade carnage as six people stabbed, sex attacks reported and police officer slashed A man was stabbed minutes from Arsenal's Emirates Stadium as crowds gathered to celebrate the club winning the Premier League title for the first time in 22 years Six people were stabbed and a police officer was slashed with a knife at the Arsenal Champions Parade on Sunday. Met Police have said 24 people were arrested after 500 officers were deployed on the streets. Police are hunting one attacker...
Building iOS Apps with Doom Emacs
I shipped SPEEM, my first iOS app, from Doom Emacs. I don’t mean I just edited a few files in Emacs and switched back when it was time to build. I mean the whole loop: write Swift, build, boot a simulator, install the app, launch it, stream logs, restart LSP, scaffold new projects.