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Human-Centered AI for Safe Shuttle Car Routing in Underground Room-and-Pillar Coal Mines Using Graph Neural Networks
Announce Type: new Abstract: Underground room-and-pillar coal mining requires shuttle car operators to make safety-critical routing decisions under conditions of low visibility, dynamic miner movement, congestion, and limited real-time information. This paper presents a human-centered AI decision-support system that recommends safe shuttle car routes using a Graph Neural Network (GNN) trained on expert-informed synthetic data and deployed through a browser-based interface backed by cloud...
Active Nuclear Shuttling Enables Efficient Virus-Free CAR Gene Integration Using Ready-to-Use Lipid Nanoparticles
Non-viral engineering of chimeric antigen receptor T (CAR -T) cells is highly desirable to overcome the cost, safety, and scalability limitations associated with viral vectors and electroporation. However, efficient nuclear delivery and stable genomic integration of DNA in primary human T cells remain major challenges. Here, we established a virus-free CAR-T manufacturing platform using lipid nanoparticles (LNPs) combined with a nuclear localization signal (NLS) shuttle strategy.
On its 40th anniversary, we reassess 1986's SpaceCamp
Forty years ago, the future seemed just around the corner—and the vehicle that was going to take us there was NASA's Space Shuttle. Originally envisioned as part of a larger integrated space transportation system, the shuttle was billed as a fully reusable vehicle, totally unlike the one-and-done capsules of the fading Apollo era, capable of making monthly (and perhaps even weekly) ferry flights to low Earth orbit. The shuttle, it was hoped, would transform human space flight from...
New 50 cent airport bus could cost disheartened Townsville business
New 50 cent airport bus could cost disheartened Townsville business Wed 10 Jun 2026 at 5:31am In short: The Queensland government will launch a 50 cent public bus between the Townsville Airport and CBD locations this month. A shuttle service that has filled the transport gap for a decade is unsure about how the change will affect it. Kinetic's route 222 service will launch on June 26, servicing the airport, bus hub, The Strand, Breakwater ferry terminal and Palmer Street.
'Ridiculous' parking at beauty spot could be tackled with free tourist buses
It has worked in the European Alps, but could a free shuttle bus tackle traffic issues in Eryri?
Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility
Importin is a nuclear transport factor which canonically has a role in binding and shuttling NLS-containing proteins from the cytoplasm into the nucleus. Recently, it has been shown that when palmitoylated by specific palmitoyl acyl transferases, importin can partition to the plasma membrane where its roles remain widely unknown. Patients with breast cancer displaying increased importin expression have advanced tumor size, poor tumor differentiation, and reduced overall and recurrence-free...
Antarctic 'sky rivers' deliver up to 90% of snowfall, 3D algorithm suggests
Antarctic 'sky rivers' deliver up to 90% of snowfall, 3D algorithm suggests Lisa Lock Scientific Editor Robert Egan Associate Editor Atmospheric rivers act like "rivers in the sky," shuttling intense bands of warm, heavy moisture from lower to higher latitudes. When an atmospheric river encounters cold air or mountainous terrain, the moisture it carries condenses and falls as heavy rain or snow. In Antarctica, the arrival of an atmospheric river can help build surface ice mass.
Petri Net Modeling and Deadlock-Free Scheduling of Attachable Heterogeneous AGV Systems
arXiv:2508.00724v2 Announce Type: replace Abstract: The increasing demand for flexible automation has accelerated the adoption of heterogeneous automated guided vehicles (AGVs). This work investigates a new scheduling problem in a material transportation system consisting of attachable heterogeneous AGVs, including carriers and shuttles, that flexibly attach and detach for cooperative task execution. While such collaboration enhances operational efficiency, the attachment-induced...