Sol\'e
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Perfect codes in weakly metric association schemes
Announce Type: replace-cross Abstract: The Lloyd Theorem of (Sol\'e, 1989) is combined with the Schwartz-Zippel Lemma of theoretical computer science to derive non-existence results for perfect codes in the Lee metric, NRT metric, mixed Hamming metric, and for the sum-rank distance. The proofs are based on asymptotic enumeration of integer partitions. The framework is the new concept of {\em polynomial} weakly metric association schemes.
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
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