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Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling

Across species, germ cells divide and differentiate as interconnected units, termed cysts. These cysts are generated through reiterative rounds of mitosis followed by incomplete cytokinesis to generate stable ring canals (RCs). Despite the ubiquity of germ cell incomplete cytokinesis, it is still unclear how this program is mechanistically regulated across multiple cell cycles to promote integrity of the cyst.

bioRxiv 4d ago