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Staphylococcus, Rothia

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Altered Tonsillar Microbiome in Children with Down Syndrome and Obstructive Sleep Apnea

Background and Objectives: Children with Down syndrome (DS) have a high prevalence of obstructive sleep apnea (OSA) due to anatomic, neuromuscular, immunological and metabolic factors, yet the contribution of the tonsillar microbiome to airway obstruction in this population remains unexplored. We hypothesized that DS-associated OSA would be associated with a distinct tonsillar microbiome compared to non DS OSA. Methods: Tonsillar tissue from 22 DS and 18 NDS participants were analyzed by 16S...

bioRxiv 9d ago