Synuclein
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Related Articles from SNS
α-Synuclein and γ-Tubulin Cooperatively Regulate Activity-Evoked Presynaptic Microtubule Nucleation to Gate Dopamine Release
alpha-Synuclein has long been implicated in the regulation of synaptic activity, but the molecular basis that underlies this function has been elusive. Here, we identify a microtubule (MT)-dependent mechanism through which alpha-synuclein regulates synaptic dopamine release. Using live imaging of cultured dopaminergic neurons, we visualize dynamic MTs at individual presynaptic boutons and show that neuronal activity triggers local gamma-tubulin-dependent MT nucleation.
Groundbreaking blood test could detect Alzheimer's disease '17 years early'
Groundbreaking blood test could detect Alzheimer's disease '17 years early' This sensor could also predict the likelihood of developing Parkinson's disease An experimental blood test could detect a devastating disease almost two decades before a typical diagnosis. A new report has found that this test could predict Alzheimer’s disease 17 years earlier than usual. The findings, published in the Journal of Physical Chemistry B, also suggest that this test could detect Parkinson’s disease early.
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists found the hidden switch fueling alzheimer’s brain inflammation Scientists may have found a hidden Alzheimer’s “inflammation switch”—and turning it off protected brain connections in early studies. - Date: - May 31, 2026 - Source: - Scripps Research Institute - Summary: - Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically...